| 新辅助化疗对宫颈癌组织中微血管密度表达的影响 |
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| 引用本文： | 雷华江,岳军,孙红兵. 新辅助化疗对宫颈癌组织中微血管密度表达的影响[J]. 西部医学, 2011, 23(5): 820-821,824. DOI: 10.3969/j.issn.1672-3511.2011.05.007 |
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| 作者姓名： | 雷华江 岳军 孙红兵 |
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| 作者单位： | 四川省人民医院,四川成都,610072 |
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| 摘 要： | 目的观察新辅助化疗（NACT）的临床疗效以及NACT前后宫颈癌组织中微血管密度（MVD）的变化。方法采用免疫组化SP法检测29例宫颈鳞癌组织NACT前后CD34的表达。结果 29例宫颈癌患者接受NACT后,临床完全缓解（CR）4例（13.8%）,部分缓解（PR）21例（72.4%）,总有效率（CR＋PR）86.2%;在所有接受NACT的29例宫颈癌组织中,MVD水平在NACT后（13.57±5.60）较NACT前（20.65±7.17）亦有明显下降（P〈0.05）;临床有效组MVD计数在NACT后（14.27±5.49）较NACT前（22.17±6.55）显著下降（P〈0.05）,临床无效组MVD计数在NACT后（19.02±5.70）较NACT前（24.98±9.42）亦有明显下降（P〈0.05）。结论 NACT对宫颈癌有效;NACT后MVD表达下降。NACT发挥效应的机制之一可能为抑制肿瘤血管生成。
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| 关 键 词： | 宫颈癌 新辅助化疗 微血管密度 |
Influence of neoadjuvant chemotherapy on expression of MVD |
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| LEI Hua-jiang,YUE Jun,SUN Hong-bing. Influence of neoadjuvant chemotherapy on expression of MVD[J]. , 2011, 23(5): 820-821,824. DOI: 10.3969/j.issn.1672-3511.2011.05.007 |
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| Authors: | LEI Hua-jiang YUE Jun SUN Hong-bing |
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| Affiliation: | LEI Hua-jiang,YUE Jun,SUN Hong-bing (The People Hospital of Sichuan,Chengdu 610072) |
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| Abstract: | Objective To investigate the clinical effect of neoadjuvant chemotherapy(NACT) and its influence on the expressions of MVD.Methods The expressions of CD34 were determined by immunohistochemistry in 29 cases of cervical cancer before and after NACT.Results Among the 29 cases treated with NACT,4(13.8%) were complete remission(CR),21(72.4%) partial remission(PR).The total effective rate of NACT(CR+PR) was 86.2%.The expressions of MVD decreased dramatically after NACT.3.In cases who reacted positively to NACT,t... |
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| Keywords: | Cervical cancer NACT Midkine Microvessel density |
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