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| CYP2D6基因G4268C和ERCC1基因C8092A位点的单核苷酸多态性与肺癌遗传易感性 | |
| 引用本文： | 康辉,赵俊华,张娇娇.CYP2D6基因G4268C和ERCC1基因C8092A位点的单核苷酸多态性与肺癌遗传易感性[J].现代肿瘤医学,2011,19(7):1275-1279. |
| 作者姓名： | 康辉 赵俊华 张娇娇 |
| 作者单位： | 1. 中国医科大学院附属第一医院检验科,辽宁,沈阳,110001 2. 中国医科大学94期临床医学七年制班,辽宁,沈阳,110001 3. 中国医科大学附属第四医院检验科,辽宁,沈阳,110032 |
| 摘 要： | 目的:探讨辽宁地区CYP2D6基因G4268C和ERCC1基因C8092A位点的单核苷酸多态性对肺癌发生的影响。方法:采用病例-对照研究方法,选取肺癌患者和健康对照者各200例。应用KI法快速抽提人外周血基因组DNA,PCR-RFLP的方法检测CYP2D6基因G4268C和ERCC1基因C8092A位点的单核苷酸多态性。结果:G4268/G、G4268/C和C4268/C这3种基因型在病例和对照组的分布频率分别为1.50%、58.00%、40.50%和2.50%、44.00%、53.50%,非C4268/C基因型的个体发生肺癌的风险是C4268/C基因型个体的1.73倍(95%CI=1.02-2.95),在腺癌中OR=2.75(95%CI=1.27-5.94);按吸烟情况进行分层分析后发现不吸烟者及轻度吸烟者中携带非C4268/C基因型的个体患肺癌的风险显著增高,OR值为2.09(95%CI=1.09-4.25)和3.41(95%CI=1.24-9.93);非A8092/A基因型的个体发生肺癌的风险是A8092/A基因型个体的0.98倍(95%CI=0.52-2.17)。结论:C4268/C基因型在不吸烟者和轻度吸烟者中可能作为保护因素而降低肺癌的易感性,ERCC1 C8092A多态性与肺癌易感性无相关性。 |
| 关 键 词： | 细胞色素P450CYP2D6 单核苷酸多态性 肺癌遗传易感性 |
Single nucleotide polymorphysims of CYP2D6 gene G4268C and ERCC1 gene C8092A and their genetic susceptibility to lung cancer |
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| KANG Hui,ZHAO Jun-hua,ZHANG Jiao-jiao.Single nucleotide polymorphysims of CYP2D6 gene G4268C and ERCC1 gene C8092A and their genetic susceptibility to lung cancer[J].Journal of Modern Oncology,2011,19(7):1275-1279. | |
| Authors: | KANG Hui ZHAO Jun-hua ZHANG Jiao-jiao |
| Institution: | KANG Hui1,ZHAO Jun-hua2,ZHANG Jiao-jiao31Department of Medical Laboratory,First Affiliated Hospital of China Medical University,Shenyang 110001,China,2Clinical Medicine Department of Seven-year 94K,China Medical University,3 Department of Medical Laboratory,Fourth Affiliated Hospital of China Medical University,Shenyang 110032,China. |
| Abstract: | Objective:To evaluate the impact of single nucleotide polymorphysims of CYP2D6 gene G4268C and ERCC1 gene C8092A on the lung cancer occurrence in Liaoning province.Methods:A case-control study was conducted included 200 lung cancer patients and 200 control subjects.KI method was used to isolate human genomic DNA from whole blood.PCR-RFLP was used to identify CYP2D6 gene G4268C,C188T and ERCC1 gene C8092A genotyes of polymorphysims.Results:The distribution frequency of G4268/G,G4268/C and C4268/C were 1.50%,... |
| Keywords: | cytochromes P450CYP2D6 single nucleotide polymorphism genetic susceptibility to lung cancer |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |