| 血管紧张素转化酶基因多态性与子痫前期 |
| |
| 引用本文： | 岳本明,何国琳,刘兴会.血管紧张素转化酶基因多态性与子痫前期[J].西部医学,2011,23(5):850-853. |
| |
| 作者姓名： | 岳本明 何国琳 刘兴会 |
| |
| 作者单位： | 四川大学华西第二医院,四川成都610041;石家庄市第四医院,河北石家庄050012 |
| |
| 基金项目： | 四川省科委科研基金资助项目 |
| |
| 摘 要： | 目的探讨孕妇和新生儿血管紧张素转化酶（ACE）基因变异是否与子痫前期有关联。方法应用多聚酶链反应-限制性片段长度多态性分析法（PCR-RFLP）,对四川地区43例汉族子痫前期患者和44例健康对照孕妇及其两组新生儿血管紧张素转化酶基因多态性进行检测;同时用紫外分光光度法检测孕妇和新生儿脐血血管紧张素转化酶活性水平。结果子痫前期组和正常孕妇组ACE基因D等位基因频率两组比较无统计学差异（37.2%vs 29.5%,P〉0.05）;早发型子痫前期组和晚发型子痫前期组ACE基因D等位基因频率比较无统计学差异（32.4%vs 40.4%,P〉0.05）;子痫前期新生儿组和正常新生儿组ACE基因D等位基因频率比较无统计学差异（47.1%vs 32.5%,P〉0.05）。子痫前期组DD基因型携带者较II基因型携带者ACE活性水平显著增高（44.01±12.41 vs 29.96±11.26,P〈0.05）。结论本研究未发现孕妇及新生儿ACE基因变异与子痫前期有关,但子痫前期组DD基因型携带者ACE活性水平显著增高。
|
| 关 键 词： | 子痫前期 ACE 基因型 多态性 |
Polymorphisms of angiotensin-converting enzyme gene in pre-eclampsia |
| |
| YUE Ben-ming,HE Guo-lin,LIU Xing-hui.Polymorphisms of angiotensin-converting enzyme gene in pre-eclampsia[J].Medical Journal of West China,2011,23(5):850-853. |
| |
| Authors: | YUE Ben-ming HE Guo-lin LIU Xing-hui |
| |
| Institution: | YUE Ben-ming1,2,HE Guo-lin,LIU Xing-hui(1.West China Second Hospital,Sichuan University,Chengdu 610041,2.The Forth Hospital of Shijiazhuang,Shijiazhuang 050011) |
| |
| Abstract: | Objective To observe the relationship between the genotype and allele frequency of angiotensin-converting enzyme(ACE) gene in mothers and fetus and pre-eclampsia.Methods Using the technique of polymerase chain reaction and restriction fragment length polymorphism,the relationship of the polymorphisms of ACE was analyzed between in 43 pregnant women with preeclampsia and 44 healthy pregnant women,including their fetus.Results No significant differences in allele and genotype frequencies of ACE gene were foun... |
| |
| Keywords: | ACE |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
