| 细胞分裂与癌发生机制研究进展 |
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| 引用本文： | 郭兰生,张学斌.细胞分裂与癌发生机制研究进展[J].现代肿瘤医学,2011,19(7):1442-1444. |
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| 作者姓名： | 郭兰生 张学斌 |
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| 作者单位： | 1. 陕西中医学院基础医学部,分子病理研究室,陕西,咸阳,712046
2. 西安交通大学第一附属医院病理科,陕西,西安,710061 |
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| 摘 要： | 基于肿瘤病理及流行病学的长期观察,结合细胞生物学新成就,发现常见肿瘤发生与细胞分裂潜能关系密切。细胞分裂是个体生长发育及组织损伤后再生修复时必不可少的生物学行为,由于细胞分裂潜能是有限的,频繁分裂将使局部细胞的分裂潜能提前耗竭,籍此发生的细胞重新选择为细胞永生化、恶性变创造了条件。
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| 关 键 词： | 细胞分裂 传代培养 永生化 细胞终末状态 失分化 |
Cell division and oncogenesis |
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| GUO Lan-sheng,ZHANG Xue-bin.Cell division and oncogenesis[J].Journal of Modern Oncology,2011,19(7):1442-1444. |
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| Authors: | GUO Lan-sheng ZHANG Xue-bin |
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| Institution: | 1Institue of Molecular Pathology,Basic Medical College of Shaanxi Chinese Medicine,Xianyang Shaanxi 712046,China;2Department of Pathology,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China. |
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| Abstract: | Base on tumor pathology and epidemiology of long-term observations,combined with new progress in cell biology,it was found that common tumorigenesis associated with the potential loss of cell divisions.Cell division is essential biological behavior when individual growth and regeneration after injury.Because cell division potential is limited,frequent cell division will induce the loss of cell division potential.Thus,as the result the accompanied cell senescence and cell option create the condition for immortal cell. |
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| Keywords: | cell division subculture immortalization cell terminal loss of differentiation |
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