微创置管胸腔内灌注顺铂和紫杉醇治疗肺癌恶性胸腔积液

摘要: 目的 评价微创置管胸腔闭式引流结合胸腔内局部灌注顺铂和紫杉醇联合化疗治疗恶性胸腔积液的临床价值。方法 45例肺癌恶性胸腔积液患者被单盲随机分为联合化疗组和对照组，两组均应用微创置管胸腔闭式引流结合局部化疗，联合化疗组所用药物为顺铂＋紫杉醇，对照组所用药物为单药顺铂，观察胸腔积液控制情况及患者生活质量。 结果 联合化疗组胸液控制有效率为86.96％，完全缓解率69.57％； 对照组有效率为50.00％，完全缓解率为36.36％，差异有统计学意义（P＜0.05）。联合化疗组生活质量好转优于对照组。 结论 微创置管胸腔闭式引流结合局部顺铂和紫杉醇联合化疗在有效控制肺癌恶性胸腔积液、提高患者生存质量方面明显优于单药化疗,值得推广应用。

Perfusion of paclitaxel and cisplatin via catheterization in pleural cavity to patients with lung cancer combining malignant pleural effusions.

【Abstract】 Objective To evaluate the efficacy and safety of perfusion of paclitaxel and cisplatin via catheterization in pleural cavity for malignant pleural effusions. Methods Forty-five patients with histology confirmed lung cancer, who met the selection criteria were enrolled in this study between March 2004 and March 2007. They received catheterization in pleural cavity and were randomly divided into two groups. The control group (22 cases) were perfused with cisplatin only. The treatment group (23 cases) were perfused with cisplatin and paclitaxel. Results The response rate of treatment group was 86.96%, and 50.00% for the control group（P＜0.05）. Conclusions The efficacy and safety of perfusion of paclitaxel and cisplatin via catheterization in pleural cavity for malignant pleural effusions is of promise. It can improve the life quality of the patients and it worth further studying.