Anticonvulsant action of thiabendazole |
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| Authors: | C Shashindran I S Gandhi N S Parmar |
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| Affiliation: | Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research Pondicherry 605006, India |
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| Abstract: | Thiabendazole was found to be specifically effective against maximal electroshock seizures in albino rats. It produced a significant dose-dependent decrease in the duration of the tonic extensor phase of hind legs. The ED50 was similar for oral or s.c. administration. PTZ-induced convulsions were unaffected by lower doses but aggravated by the higher dose studied. |
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| Keywords: | Thiabendazole Pentylenetetrazole Maximal electroshock seizure |
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