胃癌病人胃液中端粒酶活性的检测意义

目的:运用端粒酶半定量检测方法对病人的胃液进行检测,比较原发性胃癌、胃癌癌前病变和对照组病人胃液中端粒酶活性及胃癌病人术前术后胃液端粒酶活性,总结出其中的规律,为胃癌的基础研究和临床检测提供理论依据。方法:对比分析22例胃癌病人、14例癌前病变病人、15例对照组病人和18例胃癌术后病人胃液端粒酶活性的检测结果。结果:端粒酶活性(OD值)平均值为:胃癌组(0.755±0.107)>癌前病变组(0.464±0.078)>对照组(0.265±0.073),且每两组之间的差异均有统计学意义,P值均为0.000;术前组(0.758±0.107)>术后组(0.425±0.085),两组之间的差异有统计学意义,P=0.000。结论:端粒酶的活化是胃癌癌变过程的一个早期事件,端粒酶活性的检测有可能成为胃癌早期诊断、术后检测手术效果和术后复发检测的指标。

The Significance of the Telomerase Activity in Gastric Juice of Gastric Cancer

Objective：By measure semiquantitatively the telomerase activity in gastric juice of patients,compare the difference of the patient gastric juice＇s telomerase activity of gastric cancer,precancerous lesion,control group,preoperative and postoperative,to summary regularity,to provide proof to the basic research and the clinic detection.Methods：The gastric juice＇s telomerase activity of 22 gastric cancer,14 precancerous lesion,15 control group and 18 postoperative were detected and compared.Results：The mean telomerase activity is：the gastric juice of gastric cancer group（0.755±0.107）precancerous lesion group（0.464±0.078）control group（0.265±0.073）,the difference among them and every both is significant（P=0.000）;preoperative group（0.758±0.107）Postoperative group（0.425±0.085）,the difference between them is significant（P=0.000）.Conclusion：The reactivity of telomerase is an early event in the pathogenesis process of gastric cancer.The analysis of telomerase activity can be adopted as a index for early diagnosis of gastric cancer,prognostic judgement and postoperative recurrence.