试管婴儿与自然受孕儿早产儿视网膜病变发病率的相关研究

目的 探讨自然受孕儿与试管婴儿的早产儿视网膜病变（ROP）发病率差异性及相关影响因素分析.方法 回顾性分析2008年1月至2012年4月间就诊于温州医科大学附属第二医院＆amp;育英儿童医院的早产儿共1 183例的临床资料,将其中1 058例自然受孕儿设为Ⅰ组,125例试管婴儿设为Ⅱ组,将ROP筛查结果记录,对两组ROP发病率差异性进行pear-son x2检验,将胎数、出生体质量、孕周、新生儿呼吸窘迫综合征、动脉导管未闭、新生儿高胆红素血症、颅内出血、新生儿窒息、先天性心脏病、新生儿贫血、新生儿败血症、支气管肺发育不良等疾病与ROP进行spearman相关性统计学分析.结果 Ⅰ组中ROP有138例,发病率为13.0％;Ⅱ组中ROP有17例,发病率为13.6％,两组ROP发病率差异无统计学意义（P＞0.05）.以胎数、出生体质量、孕周分类,两组的ROP发病率差异无统计学意义（P＞0.05）.出生体质量、孕周与ROP呈负相关（r=-0.13,-0.159,P＜0.05）;胎数与ROP无关（P＞0.05）;新生儿呼吸窘迫综合征与ROP呈正相关（r=0.096,P＜0.05）;动脉导管未闭等疾病与ROP均无关（P＞0.05）.结论 温州地区自然受孕儿与试管婴儿ROP发病率没有显著性差异.

A survey on retinopathy of prematurity of in vitro fertilization versus natural conception

Objective To investigate whether the incidence and severity of retinopathy of prematurity （ROP） differs between infants conceived naturally and those who were in vitro fertilization （IVF）,and to analyze ROP-related factors,with a comparative case series.Methods This was a study on premature infants who required screening and treatment of ROP in the Second Affiliated Hospital ＆ Yuying Children＇s Hospital of Wenzhou Medical University,carried out between January 2008 and April 2012.One thousand and one hundred eighty three infants met the study criteria and were divided into two groups：natural conception （group Ⅰ,1058 infants） and IVF （group Ⅱ,125 infants）.Multiple variables were recorded,including birth weight （BW）,gestational age （GA）,number of births （NOB,singleton/twins/triplets）,type of conception （natural conception/IVF）,neonatal respiratory distress syndrome （NRDS）,patent ductus arteriosus （PDA）,neonatal asphyxia,neonatal hyperbilirubinemia （NHB）,intracranial hemorrhage （IH）,congenital heart disease （CHD）,neonatal anemia,neonatal sepsis,and bronchopulmonary dysplasia （BPD）.The results of ophthalmological examinations were also recorded.The incidence of ROP between groups was compared with the Pearson Chi-square test.We applied Spearman correlation analysis to identify the variables that were most significantly associated with ROP.Results There were 138 infants of ROP in group Ⅰ （total 1058,13.0%）,and 17 in group Ⅱ （total 125,13.6%）,without significant difference in the presence of ROP between two groups （P 〉 0.05）.No significant difference was found in the presence of ROP affected by BW,GA,NOB,NRDS and other diseases between two groups （P 〉 0.05）.A significantly inverse association was found between ROP and BW （P 〈 0.05）,and between ROP and GA （P 〈 0.05）.No association was found between ROP and NOB （P 〉 0.05）.There was no significant difference in the presence of diseases between infants conceived natu