天智颗粒联合尼麦角林治疗血管性认知功能障碍的临床疗效观察

血管性认知功能障碍（vascular cognitive im-pairment，VCI）通常是指由各种血管性因素引起的从轻度认知功能损害到痴呆的一大类认知障碍综合征[1]。随着生活水平提高和社会人口老龄化，脑血管疾病发病率上升，血管性认知功能障碍发病率也正逐年增加，给社会和家庭带来沉重的负担[2]。我们联合使用天智颗粒与尼麦角林，治疗血管性认知功能障碍患者[3]，疗效较好，报道如下。

The Clinical Effect Observation of Tianzhi granules Combined with Nicergoline in Treatment of Vascular Cognitive Impairment

Objective: To investigate the efficacy of Tianzhi granules combined with nicergoline in treatment of patients with vascular cognitive impairment. Method: 93 patients with vascular cognitive impairment were randomly divided into 3 groups,which were respectively treated with Tianzhi granules,nicergoline and both of them. In order to assess the efficacy,we compared MMSE and ADL scale between 3 groups,also between before and after 24 weeks treatment in each group. Results: MMSE and ADL scale have been higher after treatment (P <0.05). Both scales of the combined medicine group are higher than two pure medicine groups,and the diffence between them is statistically significant(P <0.05). Conclusions: Both of Tianzhi granules and nicergoline can improve cognitive function and behavioral ability of patients with vascular cognitive impairment,and combined use of them has better efficacy,which is worthy of clinical application and promotion.