Quantitative analysis of visual field and optic disk in glaucoma: retinal nerve fiber bundle-associated analysis |
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| Authors: | A G M Jünemann P Martus M Wisse J Jonas |
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| Institution: | (1) Department of Ophthalmology, University Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany, e-mail: anselm.juenemann@augen.med.uni-erlangen.de, Tel.: +49-9131-853001, Fax: +49-9131-856401, DE;(2) Department of Medical Informatics, Biometry and Epidemiology, University Erlangen-Nürnberg, Waldstrasse 6, 91054 Erlangen, Germany, DE |
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| Abstract: | Background: A study was performed to evaluate whether visual field analysis using a perimetric nerve fiber bundle map gives information
additional to global visual field indices and cumulative defect curves for early glaucoma diagnosis. Methods: One hundred and four control subjects, 124 patients with ocular hypertension (OHT), 97 patients with high-tension glaucoma
without visual field defects (preHTG) and 91 patients with open-angle glaucoma with visual field defects 30 low-tension glaucoma
(LTG), 61 high-tension glaucoma (HTG)] were included in this study. Correlation analyses were performed between (a) global
visual field indices and total neuroretinal rim (NRR) area; (b) local mean values of four visual field areas and the NRR area
of the corresponding four optic disk sectors; and (c) local mean values of 10 perimetric nerve fiber bundles (PNFB1–10) according
to Weber and Ulrich (1991) and the four optic disk sectors. The correlations were adjusted for global mean defect and total
NRR. Results: There were no significant correlations between NRR area and visual field in control subjects or in patients with OHT or preHTG
for all three analyses. Significant correlations were found between the global visual field indices and the total NRR area
for LTG and HTG. Significant correlations between local mean defects and NRR area of corresponding optic disk sectors were
found only in LTG for the superior and inferior visual field area and the PNFB covering these areas. Conclusion: The method used for visual field analysis and sectorization of the optic disk does not give additional information on visual
field defects in patients with normal global visual field indices and a normal cumulative defect curve. The nerve fiber bundle-related
visual field analysis allows the topographical determination and quantification of glaucomatous damage.
Received: 4 February 1999 Revised: 20 September 1999 Accepted: 4 October 1999 |
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