改良人工食管结构预防新生食管狭窄

目的观察改良人工食管结构对术后新生食管狭窄的影响,为完善人工食管设计提供实验数据。方法采用犬食管缺损模型,实验组(n=10)植入复合结构管,术后新生食管狭窄者置入食管支架。对照组(n=30)植入单一结构管,术后新生食管狭窄者行扩张治疗,治疗失败后行支架置入。结果实验组人工食管平均脱管时间为19·10d,明显低于对照组的39·07d(t=15·6,P=0·000)。与对照组相比,实验组无人工食管脱管后梗阻发生。两组术后新生食管狭窄发生率差异无显著性。结论复合结构管可缩短脱管持续时间而安全脱管。

Experimental study of preventing postoperative stenosis by modifying artificial esophagus in dogs

Objective To observe the effect of the modified artificial esophagus on postoperative stenosis in dogs. Methods The models of defected esophagus were established in dogs. The double-layered membrane tube (modifying type) was implanted in the test group(n=10) and the esophageal stent was further inserted when the stenosis occurred. The single pattern tube (original type) was transplanted to the control group (n=30). The dilation treatment was performed to relieve the postoperative stenosis; alternatively, the esophageal stent was implanted in the unsuccessful dogs. Results The average artificial esophagus removal time was 19.10 days in the test group, which was significantly lower than 39.07 days in the control group(t=15.6,P=0.000).No obstruction after removal was observed in the experimental group. The incidence of postoperative stenosis had no significant difference between these two groups. Conclusion The double-layered membrane tube can make the tube removal safer by shortening the removal time.