Tumor imaging with carbon-11 labeled alpha-aminoisobutyric acid (AIB) in a patient with advanced malignant melanoma |
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| Authors: | Peter S. Conti Peter P. Sordillo Bernard Schmall Richard S. Benua James R. Bading Rodney E. Bigler John S. Laughlin |
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| Affiliation: | (1) Memorial Sloan-Kettering Cancer Center, 10021 New York, NY, USA;(2) Department of Radiology, The Johns Hopkins Hospital, 601 N. Broadway, 21205 Baltimore, MD, USA |
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| Abstract: | A 29 year-old-man presenting with advanced metastatic malignant melanoma was successfully imaged using carbon-11 (11C) labeled alpha-aminoisobutyric acid (AIB), a synthetic, non-metabolized amino acid transported into viable cells by the A-type, or alanine-preferring, amino acid transport system. Tumor located in the hilum of the lung was well visualized with 11C-AIB prior to chemotherapy. A gallium image with liver subtraction using 99mTc-sulfur colloid demonstrated regions of increased activity in liver which correlated with regions of increased activity on the 11C-AIB liver image. |
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| Keywords: | 11C-AIB Tumor imaging Malignant melanoma |
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