辛伐他汀治疗肾移植术后高脂血症的临床应用研究

目的 探讨他汀类药物对肾移植术后血脂异常的疗效。方法 将36例术后1年以上的高脂血症患者（血浆胆固醇总量水平＞6.35 mmol/L,低密度脂蛋白＞3.1 mmol/L）作为研究对象。所有患者均采取低脂饮食，测定患者血总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、甘油三酯（TG）、载脂蛋白A（apoA）、载脂蛋白B（apoB）、肌酐（Cr），谷草转氨酶（GOT）及谷丙转氨酶（GPT）等各参数数值；然后给予辛伐他汀10 mg，每晚一次口服，测定用药后1，3，6，12个月后以上各参数值的变化。结果 肾移植术后高脂血症患者LDL较TC增高更为明显；用药后患者TC,LDL,TG,apoB分别于用药后第1,3,6,12个月时均出现显著性下降（P<0. 01），LDL的下降尤为明显；HDL于用药后第12个月时出现显著增高（P<0.05）；其余各项指标无显著变化；结论 辛伐他汀可有效、安全地用于治疗肾移植术后血脂异常。 【关键词】 肾移植 辛伐他汀 高脂血症

The Study of Clinical Application on Simvastatin in the Treatment of Hyperlipidemia After Renal Transplantation

Abstract] Objective To investigate the curative effect of Simvastatin treating hyperlipidemia after renal transplantation. Methods Thirty-six patients with hyperlipidemia (serum total cholesterol＞6.35mmol/L, low-density lipoprotein ＞3.1mmol/L)who underwent renal transplantation for more than one year were included. Low-fat diet was given to those patients. The changes of total cholesterol(TC),high-density lipoprotein(HDL),low-denstiy lipoprotein(LDL),triglyceride(TG)，aproprotein A(apoA), aproprotein B(apoB), creatinine(Cr), glutamic oxalacetic transaminase(GOT), glutamic pyruvic transaminase(GPT) were measured before and after 1,3,6,12 months of Simvastatin therapy(10mg,qd). Results The rise of LDL is more apparently compared to that of TC in hyperlipidemia after renal transplantion; after treatment with simvastatin, TC, LDL, TG and apoB were significantly reduced at 1,3,6,12 month respectively, especially LDL. HDL was significantly higher at 12 month. No significance was found at other indexs. Conclusion Simvastatin can treat hyperlipidemia after renal transplantation effectively and safely.