应用硫酸镁治疗胎儿生长迟缓

目的　探讨胎儿生长迟缓 (intrauterinegrowthretardation ,IUGR)孕妇的静脉血与新生儿脐静脉血中镁离子含量的变化及其与新生儿体重的关系。方法　将 39例IUGR孕妇随机分为治疗 1组 14例 ,治疗 2组 14例 ,未治疗组 11例。治疗 1组用 10 %葡萄糖 5 0 0ml 复方丹参液 14ml 低分子右旋糖酐 5 0 0ml静脉滴注 ;治疗 2组除有与治疗 1组相同的处方外 ,再加用 5 %葡萄糖 5 0 0ml 2 5 %硫酸镁 2 0ml静脉滴注 ,并以同期分娩的 12例正常孕妇为对照组。采用全自动生化分析仪 ,测定 4组孕妇的肘静脉血和新生儿脐静脉血中的镁离子含量。结果　治疗 1组孕妇静脉血中镁离子含量(0 6 9± 0 0 5 )mmol/L]和未治疗组 (0 6 8± 0 0 2 )mmol/L]比较 ,差异无显著性 (P >0 0 5 ) ,和治疗 2组 (1 0 6± 0 0 9)mmol/L]比较 ,差异有显著性 (P <0 0 5 ) ,各组新生儿脐血镁离子含量比较 ,差异有极显著性 (P <0 0 1) ,对照组和治疗 2组、未治疗组和治疗 1组比较 ,差异无显著性 (P >0 0 5 ) ,其余各组间比较 ,差异有极显著性 (P <0 0 1) ,各组胎盘重量比较 ,差异有极显著性 (P <0 0 1) ,各组新生儿体重比较 ,差异有显著性 (P <0 0 5 )。结论　镁缺乏是IUGR发生的原因之一 ,中晚期孕妇适量补充镁有预防和治疗IUGR的作用

Treatment of intrauterine growth retardation with magnesium sulfate

OBJECTIVE: To study the relationship between magnesium level in umbilical vein and mother's peripheral blood with intrauterine growth retardation (IUGR) and fetal weight. METHODS: 39 pregnant women with IUGR were randomly divided into 3 groups: Group 1 (n = 14): The patients were treated with 10% glucose 500 ml + danshen compound 14 ml + low molecular weight dextran 500 ml i.v.; Group 2 (n = 14): in addition to the same treatment as in group 1, 25% magnesium sulfate 20 ml in 5% glucose 500 ml i.v. was given; Group 3 (n = 11): no treatment was given; and another 12 normal term delivery women were served as control. Magnesium concentration levels were determined in both maternal peripheral blood and their fetal umbilical vein. RESULTS: Maternal serum magnesium level was higher in Group 2 (1.06 +/- 0.09) mmol/L than that in Group 1 (0.69 +/- 0.05) mmol/L (P < 0.05), while there was no significant difference between Group 1 and Group 3. The serum magnesium levels in both mother and fetal umbilical vein of normal pregnancy and of Group 2 were significantly higher than those of Group 1 and 3 (P < 0.01), so did the birth weight of their newborns (P < 0.05). CONCLUSION: Magnesium deficiency might be one of the causes of IUGR, and magnesium sulfate treatment was effective.