| PPIs抑制空泡型质子泵逆转胃癌化疗多药耐药 |
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| 引用本文： | 李建琦,陈敏,邹晓平.PPIs抑制空泡型质子泵逆转胃癌化疗多药耐药[J].世界华人消化杂志,2011(31):3201-3206. |
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| 作者姓名： | 李建琦 陈敏 邹晓平 |
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| 作者单位： | 南京大学医学院附属鼓楼医院消化科; |
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| 基金项目： | 国家自然科学基金资助项目,No.81071816,No.81101814; 中央高校基本科研业务费基金资助项目,No.021414340018~~ |
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| 摘 要： | 肿瘤多药耐药性影响着胃癌化疗的效果,肿瘤微环境变化与多药耐药密切相关,而酸化与缺氧是微环境的两大特征.肿瘤细胞内无氧酵解生成大量H+,但却仍能维持胞内中性pH环境,推测与调节肿瘤泌酸功能的空泡型质子泵密切相关.胞外pH值的酸化可活化胞内PI3K/Akt信号通路,活化mTOR,上调HIF-1α,进而促进P-gp及MRP1...
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| 关 键 词： | 质子泵抑制剂 胃癌 多药耐药 |
PPIs reverse multidrug resistance to chemotherapy in gastric cancer by inhibiting vacuolar H~+_-ATPase signal pathway |
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| Jian-Qi Li,Min Chen,Xiao-Ping Zou.PPIs reverse multidrug resistance to chemotherapy in gastric cancer by inhibiting vacuolar H~+_-ATPase signal pathway[J].World Chinese Journal of Digestology,2011(31):3201-3206. |
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| Authors: | Jian-Qi Li Min Chen Xiao-Ping Zou |
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| Institution: | Jian-Qi Li,Min Chen,Xiao-Ping Zou,Department of Gastroenterology,the Affi liated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,Jiangsu Province,China |
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| Abstract: | Multidrug resistance(MDR) in gastric cancer influences the effects of chemotherapy.The change in tumor microenvironment is intimately asso-ciated with multidrug resistance.Acidification and hypoxia are the two major characteristics of tumor microenvironment.The glucose metabo-lism in hypoxic conditions by the neoplasms leads to an intercellular pH drift towards acid-ity.But tumor cells can maintain intracellular to neutro-alkalinity.Vacuolar H+-ATPases may be involved in this process by regulating H+ ex-cre... |
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| Keywords: | Proton pump inhibitors Gastric cancer Multidrug resistance |
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