| Th17细胞及肠道内共生菌群在炎症性肠病中的作用 |
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| 引用本文： | 李睿东,韩高雄,陶凯雄.Th17细胞及肠道内共生菌群在炎症性肠病中的作用[J].世界华人消化杂志,2011(28). |
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| 作者姓名： | 李睿东 韩高雄 陶凯雄 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院; |
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| 摘 要： | 炎症性肠病(inflammatory bowe ldisease,IBD)是一种以慢性肠道炎症性疾病,病因未明,肠道黏膜异常的免疫反应在发病中有着重要作用.最近发现一类辅助T淋巴细胞Th17细胞,能在肠黏膜中大量分泌IL-17A和IL-17F.减少肠道Th17细胞数量和其相关的细胞因子的表达能够缓解肠道炎症反应,预示Th17细胞在IBD发病中起到一定作用.肠道共生菌与IBD的发病也有着密切关系,肠道共生菌群的变化可能导致Th17细胞的数量发生改变引起炎症,或者通过其他机制和途径诱发免疫紊乱,从而使得炎症得以发生.本文就Th17细胞的分化与其在IBD中的作用,以及共生菌群和Th17细胞之间的相互联系作一综述.
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| 关 键 词： | Th17细胞 炎症性肠病 共生菌群 |
Role of interaction between Th17 cells and commensal microbiota in the pathogenesis of inflammatory bowel disease |
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| Rui-Dong Li,Gao-Xiong Han,Kai-Xiong Tao.Role of interaction between Th17 cells and commensal microbiota in the pathogenesis of inflammatory bowel disease[J].World Chinese Journal of Digestology,2011(28). |
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| Authors: | Rui-Dong Li Gao-Xiong Han Kai-Xiong Tao |
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| Institution: | Rui-Dong Li,Gao-Xiong Han,Kai-Xiong Tao,Department of General Surgery,Wuhan Union Hospital,Tongji Medical College of Huazhong University of Science and Technol-ogy,Wuhan 430022,Hubei Province,China |
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| Abstract: | Inflammatory bowel disease (IBD) is an autoim-mune disease whose etiology and pathogenesis remain incompletely understood. Th17 cells can secrete cytokines interleukin-17A and interleu-kin-17F, which play an important role in the pathogenesis of IBD. Some studies have proved that reduction of IL-17A and IL-17F can attenu-ate intestinal mucosal inflammation. Addition-ally, many studies reveal that the occurrence of IBD is correlated with commensal microbiota. Commensal microbiota can alter the number of Th17... |
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| Keywords: | Th17 cells Inflammatory bowel dis-ease Commensal microbiota |
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