| 肿瘤抗淋巴管生成研究进展 |
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| 引用本文： | 吴而回,燕敏. 肿瘤抗淋巴管生成研究进展[J]. 世界华人消化杂志, 2011, 0(24): 2555-2561 |
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| 作者姓名： | 吴而回 燕敏 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院普外科; |
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| 摘 要： | 肿瘤转移是癌症患者的主要死因之一,淋巴管转移是肿瘤转移的重要途径,研究发现VEGF-C/VEGF-D/VEGFR-3与肿瘤淋巴管生成、肿瘤转移、肿瘤预后密切相关.大量的研究证实VEGF-C/VEGF-D/VEGFR-3信号传导轴在调节肿瘤淋巴管生成中起主导作用,临床病理研究也显示VEGF-C/VEGF-D/VEGFR-...
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| 关 键 词： | 淋巴管 血管内皮生长因子 分子生物学 |
Lymphangiogenesis in cancers:a therapy target |
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| Er-Hui Wu,Min Yan. Lymphangiogenesis in cancers:a therapy target[J]. World Chinese Journal of Digestology, 2011, 0(24): 2555-2561 |
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| Authors: | Er-Hui Wu Min Yan |
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| Affiliation: | Er-Hui Wu,Min Yan,Department of General Surgery,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China |
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| Abstract: | Tumor metastasis is a major cause of death among cancer patients.The lymphatic vasculature is an important route for the metastatic spread of cancer.Recent research has indicated that vascular endothelial growth factor C(VEGF-C),VEGF-D and VEGF receptor-3(VEGFR-3) are closely related to tumor-induced lymphangiogenesis,tumor metastasis and prognosis.Numerous studies demonstrate that the VEGF-C/VEGF-D/VEGFR-3 signaling axis plays a leading role in the regulation of tumor lymphangiogenesis and is related to tu... |
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| Keywords: | Lymphatic vasculature Vascular endothelial growth factor Molecular biology |
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