| 类胰岛素生长因子与肝癌 |
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| 引用本文： | 孙芳,付汉江,铁轶,郑晓飞. 类胰岛素生长因子与肝癌[J]. 世界华人消化杂志, 2011, 0(23): 2473-2479 |
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| 作者姓名： | 孙芳 付汉江 铁轶 郑晓飞 |
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| 作者单位： | 白求恩军医学院生物化学教研室;中国人民解放军军事医学科学院放射与辐射医学研究所; |
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| 摘 要： | 肝癌是常见的恶性肿瘤之一,其病程快且预后很差.其发生是一个多因素多步骤协同的复杂过程.近来的研究报道,肝癌发生分子机制与类胰岛素生长因子体系信号通路异常相关,类胰岛素生长因子是一种多功能细胞增殖调控因子,他在胚胎发育、中枢神经系统发育及肿瘤细胞增殖等方面具有重要的生物学功能.类胰岛素生长因子的生物学活性受到包括类胰岛素...
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| 关 键 词： | 类胰岛素生长因子 类胰岛素生长因子受体-Ⅰ 肝癌 |
Insulin-like growth factors and hepatocellular carcinoma |
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| Fang Sun. Insulin-like growth factors and hepatocellular carcinoma[J]. World Chinese Journal of Digestology, 2011, 0(23): 2473-2479 |
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| Authors: | Fang Sun |
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| Affiliation: | Fang Sun,Department of Biochemistry,Bethune Military Medical College of the Chinese People's Liberation Army,Shijiazhuang 050081,Hebei Province,China Han-Jiang Fu,Yi Tie,Xiao-Fei Zheng,Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing 100850,China |
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| Abstract: | Hepatocellular carcinoma(HCC) is one of the most malignant types of cancer.It has a rapid course and carries a poor prognosis.Hepatocarcinogenesis is a complex multi-step and multifactorial process.Recent studies have discovered the association between the dysregulation of insulin-like growth factor(IGF)-related signaling pathways and pathogenesis of liver cancer IGFs are multifunctional cell proliferation regulatory factors and play an important role in feta development,central nervous system development a... |
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| Keywords: | Insulin-like growth factors Insulin-like growth factor-I receptor Hepatocellular carcinoma |
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