| 胰岛素样生长因子对克罗恩病患者的临床意义 |
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| 引用本文： | 余强,陆忠凯. 胰岛素样生长因子对克罗恩病患者的临床意义[J]. 世界华人消化杂志, 2011, 0(26) |
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| 作者姓名： | 余强 陆忠凯 |
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| 作者单位： | 南京医科大学附属苏州市立医院消化内科; |
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| 摘 要： | 目的:研究我国克罗恩病(CD)患者胰岛素样生长因子水平(IGF)的变化及临床意义.方法:收集54例CD患者的临床资料,并根据临床严重程度分为轻(20例)、中(18例)、重(16例)3组.采用酶标化学发光免疫分析的方法分别检测轻、中、重各组CD患者规范性治疗前后的外周血IGF-I和胰岛素样生长因子结合蛋白-3(IGFBP3)的结果,50例健康人群作为对照组,分析外周血IGF-I和IGFBP3对CD的临床意义.结果:(1)中重度CD患者外周血IGF-I值分别为104.78μg/L±16.28μg/L和77.50μg/L±12.46μg/L,IGFBP3值分别为2.83mg/L±1.02mg/L和1.93mg/L±0.65mg/L,均较正常对照组明显减低,并随着病情加重呈进行性下降(均P<0.05).轻度组IGF-I及IGFBP3值较对照组也有所下降,但无统计学差异;(2)中重度CD经治疗有效后IGF-I值分别为122.75μg/L±27.14μg/L和102.31μg/L±29.24μg/L,IGFBP3值分别为3.85mg/L±0.92mg/L和3.35mg/L±1.35mg/L,均较治疗前明显升高(P<0.0...
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| 关 键 词： | 胰岛素样生长因子 克罗恩病 胰岛素样生长因子结合蛋白-3 |
Clinical significance of peripheral blood levels of insulin-like growth factor in patients with Crohn's disease |
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| Qiang Yu,Zhong-Kai Lu. Clinical significance of peripheral blood levels of insulin-like growth factor in patients with Crohn's disease[J]. World Chinese Journal of Digestology, 2011, 0(26) |
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| Authors: | Qiang Yu Zhong-Kai Lu |
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| Affiliation: | Qiang Yu,Zhong-Kai Lu,Department of Gastroenterology,Suzhou Municipal Hospital Affiliated to Nanjing Medical University,Suzhou 215002,Jiangsu Province,China |
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| Abstract: | AIM:To analyze the clinical significance of peripheral blood levels of insulin-like growth factor(IGF) in patients with Crohn's disease(CD).METHODS:Fifty-four patients with CD were collected and divided into mild,moderate,and severe groups according to the severity of the disease.Enzyme-labeled chemiluminescent immunometric assay was used to detect peripheral blood levels of IGF-I and insulin-like growth factor-binding protein 3(IGFBP3) in patients before and after standard treatment to assess their associa... |
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| Keywords: | Insulin-like growth factor Crohn's disease Insulin-like growth factor-binding protein 3 |
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