| 肉桂油对胰岛素抵抗小鼠糖脂代谢的影响 |
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| 引用本文： | 陈璿瑛,彭小平,王琳,魏筱华,李文娟,何明.肉桂油对胰岛素抵抗小鼠糖脂代谢的影响[J].世界华人消化杂志,2011(33). |
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| 作者姓名： | 陈璿瑛 彭小平 王琳 魏筱华 李文娟 何明 |
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| 作者单位： | 南昌大学第一附属医院药剂科;南昌大学第一附属医院心内科;南昌大学食品科学与技术国家重点实验室;南昌大学药学院; |
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| 基金项目： | 江西省卫生厅课题基金资助项目,No.20093040 |
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| 摘 要： | 目的:研究肉桂油对胰岛素抵抗小鼠糖脂代谢的影响,探讨其作用机制.方法:采用高脂饲料喂养建立小鼠胰岛素抵抗模型,经肉桂油治疗后测定口服糖耐量及胰岛素耐受,观察体质量、血糖、血清胰岛素、甘油三酯、总胆固醇、瘦素、抵抗素、脂联素的变化.结果:肉桂油能降低胰岛素抵抗小鼠的体质量(30.3±3.6vs34.6±3.1,P<0.05)、血糖(7.6±2.2vs9.2±1.3,P<0.05)、血清胰岛素(1.3±0.1vs1.7±0.2,P<0.05)、甘油三酯(70.1±10.9vs65.4±19.5,P<0.05)、总胆固醇(93.2±13.8vs102.3±21.5,P<0.05)、瘦素、抵抗素水平,同时改善口服糖耐量,降低胰岛素抵抗.结论:肉桂油能有效改善胰岛素抵抗小鼠糖脂代谢,其作用与降低血清瘦素、抵抗素水平,增加胰岛素敏感性有关.
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| 关 键 词： | 肉桂油 胰岛素抵抗 降糖降脂作用 瘦素 抵抗素 |
Effect of volatile oil from Cinnamomi Cortex on blood glucose and lipid metabolism in insulin-resistant mice |
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| Xuan-Ying Chen,Lin Wang,Xiao-Hua Wei.Effect of volatile oil from Cinnamomi Cortex on blood glucose and lipid metabolism in insulin-resistant mice[J].World Chinese Journal of Digestology,2011(33). |
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| Authors: | Xuan-Ying Chen Lin Wang Xiao-Hua Wei |
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| Institution: | Xuan-Ying Chen,Lin Wang,Xiao-Hua Wei,Department of Pharmacy,the First Affi liated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China Xiao-Ping Peng,Department of Cardiology,China Wen-Juan Li,State Key Laboratory of Food Science and Technology,Nanchang University,Nanchang 330047,China Ming He,College of Pharmaceutical Sciences,Jia... |
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| Abstract: | AIM: To investigate the effect of volatile oil from Cinnamomi Cortex (VOCC) on blood glucose and lipid metabolism in insulin-resistant mice and to investigate the possible mechanisms involved. METHODS: Insulin resistance was induced by feeding a high-fat diet. After insulin-resistant mice were treated orally with VOCC, oral glu-cose tolerance test and insulin tolerance test were performed. The body weight, blood glucose, serum insulin, total cholesterol, triglyceride, leptin, resistin, and adiponectin were ... |
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| Keywords: | Volatile oil from Cinnamomi Cortex Insulin resistance Hypoglycemic and hypolipidemic effect Leptin Resistin |
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