| DEC205在幽门螺杆菌感染的胃黏膜中的表达 |
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| 引用本文： | 魏晓晴,吕广艳,金海威,崔颖,赵莹. DEC205在幽门螺杆菌感染的胃黏膜中的表达[J]. 世界华人消化杂志, 2011, 0(36) |
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| 作者姓名： | 魏晓晴 吕广艳 金海威 崔颖 赵莹 |
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| 作者单位： | 辽宁省医学细胞分子生物学重点实验室;大连医科大学中心实验室;大连医科大学口腔医学院基础教研室; |
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| 基金项目： | 辽宁省教育厅2009年度高等学校科研项目计划基金资助项目,No.2009A195 |
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| 摘 要： | 目的:探讨幽门螺杆菌(Helicobacter pylori,H.pylori)感染的胃黏膜与DEC205的关系.方法:对13名H.pylori感染阳性患者的胃黏膜进行内窥镜活检,以及对这13例中7例被根除H.pylori的患者的胃黏膜进行二次内窥镜活检,活检标本行冰冻组织切片后,分别进行DEC205抗体的免疫组织化学染色,以及进行DEC205抗体和CD14抗体的免疫荧光染色.结果:对比除菌成功H.pylori阴性的患者,H.pylori阳性患者胃小凹处的胃黏膜上皮细胞间DEC205的表达明显增多.胃黏膜中,DEC205与CD14表达在同一个位置,而且DEC205与CD14的表达在H.pylori感染胃黏膜中明显高于除菌成功的H.pylori阴性的患者.结论:胞吞受体DEC205在H.pylori感染的胃黏膜巨噬细胞中呈高表达.
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| 关 键 词： | 幽门螺杆菌 DEC205 胃黏膜 |
Expression of DEC205 in the gastric mucosa of Helicobacter pylori-infected patients |
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| Xiao-Qing Wei,Ying Cui,Ying Zhao,Liaoning Provincial Key Laboratory of Cell , Molecular Biology,Dalian ,Liaoning Province,China Guang-Yan Lv,Central Laboratory,Dalian Medical University,China Hai-Wei Jin. Expression of DEC205 in the gastric mucosa of Helicobacter pylori-infected patients[J]. World Chinese Journal of Digestology, 2011, 0(36) |
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| Authors: | Xiao-Qing Wei Ying Cui Ying Zhao Liaoning Provincial Key Laboratory of Cell Molecular Biology Dalian Liaoning Province China Guang-Yan Lv Central Laboratory Dalian Medical University China Hai-Wei Jin |
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| Affiliation: | Xiao-Qing Wei,Ying Cui,Ying Zhao,Liaoning Provincial Key Laboratory of Cell and Molecular Biology,Dalian 116044,Liaoning Province,China Guang-Yan Lv,Central Laboratory,Dalian Medical University,China Hai-Wei Jin,Department of Basic Sciences,School of Stomatology,China |
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| Abstract: | AIM:To investigate the expression of DEC205 in the gastric mucosa of Helicobacter pylori (H.pylori)infected patients.METHODS:Thirteen H.pylori-positive patients with gastritis received eradication therapy.Gastroscopy was performed in all the 13 patients before eradication therapy and in 7 seven patients after treatment to take gastric mucosa samples,which were used to prepare frozen section to detect the expression of DEC205 and CD14 in human gastric mucosa by immunofluorescence.RESULTS:Cells which were pos... |
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| Keywords: | Helicobacter pylori DEC205 Gastric mucosa |
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