| 急性胆道梗阻肠黏膜屏障破坏与氯离子通道-2的关系 |
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| 引用本文： | 陈振勇,王延刚,杨鹏,黄文广,周有生,冯贤松. 急性胆道梗阻肠黏膜屏障破坏与氯离子通道-2的关系[J]. 世界华人消化杂志, 2011, 0(27): 2829-2834 |
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| 作者姓名： | 陈振勇 王延刚 杨鹏 黄文广 周有生 冯贤松 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院普外科; |
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| 基金项目： | 湖北省自然科学基金资助项目,No.2010CDB08005~~ |
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| 摘 要： | 目的:探讨急性胆道梗阻肠黏膜屏障破坏与肠上皮细胞氯离子通道-2(chloride channel-2,CLC-2)的关系.方法:建立急性胆道梗阻(阻塞性黄疸)大鼠动物模型,术后7d连续注射Lubiprostone(Lu组)、类高血糖素多肽-2(GLP-2组)、两者共同使用(Lu+GLP组),以假手术组(Sham组)和阻...
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| 关 键 词： | 阻塞性黄疸 肠黏膜屏障 紧密连接蛋白 氯离子通道-2 |
Relationship between CLC-2 and intestinal mucosal barrier in rats with obstructive jaundice |
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| Zhen-Yong Chen,Yan-Gang Wang,Peng Yang,Wen-Guang Huang,You-Shen Zhou,Xian-Song Feng. Relationship between CLC-2 and intestinal mucosal barrier in rats with obstructive jaundice[J]. World Chinese Journal of Digestology, 2011, 0(27): 2829-2834 |
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| Authors: | Zhen-Yong Chen Yan-Gang Wang Peng Yang Wen-Guang Huang You-Shen Zhou Xian-Song Feng |
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| Affiliation: | Zhen-Yong Chen,Yan-Gang Wang,Peng Yang,Wen-Guang Huang,You-Shen Zhou,Xian-Song Feng. Department of General Surgery,Union Hospital,Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China |
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| Abstract: | AIM: To investigate the relationship between chloride channel-2 (CLC-2) and intestinal mucosal barrier in rats with obstructive jaundice (OJ). METHODS: Rats were randomly divided into five groups: sham operation group, OJ group, lubiprostone (Lu) group, glucagon-like peptide-2 (GLP-2) group, and Lu + GLP group. Except for the sham operation group, OJ was induced by bile duct ligation in rats of other groups. The Lu group was subcutaneously injected with LU, and the GLP-2 group was injected with GLP-2. The L... |
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| Keywords: | Obstructive jaundice Intestinal mucosal barrier Tight junction protein Chloride channel-2 |
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