| 谷氨酰胺在腹部术后肠梗阻患者保守治疗中的意义 |
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| 引用本文： | 牛志军,张谢夫,赵春临,刘涛,翟二涛. 谷氨酰胺在腹部术后肠梗阻患者保守治疗中的意义[J]. 世界华人消化杂志, 2011, 0(36) |
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| 作者姓名： | 牛志军 张谢夫 赵春临 刘涛 翟二涛 |
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| 作者单位： | 郑州大学第一附属医院胃肠外科; |
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| 摘 要： | 目的:探讨谷氨酰胺(Glutamine,Gln)在腹部术后肠梗阻患者保守治疗中保护肠黏膜屏障的作用.方法:将收治的58例有腹部手术史且临床诊断为肠梗阻的患者随机分为对照组与治疗组.对照组给予常规治疗:禁食、持续胃肠减压、维持水电解质和酸碱平衡、应用抗生素、生长抑素和全胃肠外营养(TPN)等;治疗组在上述常规治疗的基础上,给予Gln强化的TPN.治疗前对所有患者进行胃肠功能障碍评分,比较两组患者治疗前、治疗4d、治疗8d、治疗12d后血清D-乳酸浓度、肠脂肪酸结合蛋白(I FA B P)水平,记录患者肠道功能恢复时间(d),采用P e a r s o n相关、重复测量资料的方差分析及两独立样本均数比较t检验进行统计学分析.结果:肠梗阻患者外周血中D-乳酸浓度、IFABP水平与肠功能障碍评分值呈正相关(r=0.824,r=0.891,均P<0.001);随治疗时间延长,治疗组与对照组患者血清D-乳酸、IFABP水平均呈下降趋势,治疗组下降趋势更明显;治疗组肠道功能恢复时间短于对照组(6.83d±1.49d vs8.76d±1.53d),差异有统计学意义(P<0.001).结论:在腹部术后肠梗阻患者的常规治疗基础上...
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| 关 键 词： | 谷氨酰胺 肠梗阻 肠黏膜屏障 D-乳酸 肠脂肪酸结合蛋白 |
Value of glutamine in conservative treatment of patients with intestinal obstruction after abdominal operation |
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| Zhi-Jun Niu,Xie-Fu Zhang,Chun-Lin Zhao,Tao Liu,ErTao Zhai. Value of glutamine in conservative treatment of patients with intestinal obstruction after abdominal operation[J]. World Chinese Journal of Digestology, 2011, 0(36) |
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| Authors: | Zhi-Jun Niu Xie-Fu Zhang Chun-Lin Zhao Tao Liu ErTao Zhai |
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| Affiliation: | Zhi-Jun Niu,Xie-Fu Zhang,Chun-Lin Zhao,Tao Liu,ErTao Zhai,Department of Gastrointestinal Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China |
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| Abstract: | AIM:To evaluate the value of glutamine in conservative treatment of patients with intestinal obstruction after abdominal operation.METHODS:Fifty-eight patients with intestinal obstruction after abdominal operation were randomly divided into control group and treatment group.The control group received conventional treatment,including fasting,gastrointestinal decompression,maintenance of water electrolyte and acid-base balance,use of antibiotics,somatostatin,and total parenteral nutrition,while the treatment ... |
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| Keywords: | Glutamine Intestinal obstruction Gut barrier D-lactic acid Intestinal fatty acid-binding protein |
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