| TWEAK及其受体Fn14蛋白在食管鳞癌中的表达及临床病理意义 |
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| 引用本文： | 杨建萍,李晟磊. TWEAK及其受体Fn14蛋白在食管鳞癌中的表达及临床病理意义[J]. 世界华人消化杂志, 2011, 0(31) |
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| 作者姓名： | 杨建萍 李晟磊 |
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| 作者单位： | 郑州大学第一附属医院病理科;郑州大学基础医学院病理教研室河南省肿瘤病理重点实验室; |
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| 基金项目： | 河南省教育厅自然科学基金资助项目,No.2010A310008~~ |
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| 摘 要： | 目的:探讨肿瘤坏死因子样凋亡微弱诱导剂(TNF-like weak inducer of apoptosis,TWEAK)及其受体早期反应蛋白14(fibroblast growth factor-inducible 14,Fn14)表达与食管鳞状细胞癌发生、发展及浸润、转移的关系.方法:应用免疫组化法分别检测手术切除的45例食管鳞癌组织、22例癌旁不典型增生组织及22例正常食管黏膜组织中TWEAK及Fn14蛋白表达,并且对二者在食管鳞状细胞癌组织中的表达情况进行相关性分析.结果:食管鳞癌组织中TWEAK蛋白表达与癌的浸润深度、淋巴结转移及TNM分期均密切相关(χ2分别为6.455,11.645及4.185,P均<0.05);在食管鳞癌癌变过程中TWEAK蛋白表达在正常黏膜组织、癌旁不典型增生组织及癌组织中的表达率依次增高,分别为27.3%(6/22)、40.9%(9/22)、64.4%(29/45),组间比较差异具有统计学意义(χ2=9.018,P<0.05);Fn14蛋白表达也与癌的组织学分级、浸润深度、淋巴结转移及TNM分期均密切相关(χ2分别为10.873、12.513、9.244及13.137;均P...
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| 关 键 词： | 肿瘤坏死因子样凋亡微弱诱导剂 早期反应蛋白14 食管鳞状细胞癌 免疫组织化学 浸润转移 |
Clinical pathological significance of expression of TWEAK and its receptor Fn14 in esophageal squamous cell carcinoma |
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| Jian-Ping Yang,Sheng-Lei Li. Clinical pathological significance of expression of TWEAK and its receptor Fn14 in esophageal squamous cell carcinoma[J]. World Chinese Journal of Digestology, 2011, 0(31) |
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| Authors: | Jian-Ping Yang Sheng-Lei Li |
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| Affiliation: | Jian-Ping Yang,Sheng-Lei Li,Department of Pathology,the First Affiliated Hospital of Zhengzhou University,Basic Medical College of Zhengzhou University,Henan Key Laboratory of Tumor Pathology,Zhengzhou 450052,Henan Province,China |
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| Abstract: | AIM:To explore the role of TWEAK and its receptor Fn14 in the development,progression,invasion and metastasis of esophageal squamous cell carcinoma(ESCC) . METHODS:Immunohistochemistry was used to detect the expression of TWEAK and Fn14 in 45 cases of ESCC specimens,22 cases of adjacent atypical hyperplasia epithelial specimens and 22 cases of normal esophageal epithelial specimens. RESULTS:The expression of TWEAK protein was closely correlated with tumor infiltration,lymphatic metastasis and TNM grade in E... |
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| Keywords: | TWEAK Fn14 Esophageal squamous cell carcinoma Immunohistochemistry Invasion and metastasis |
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