| 益生菌制剂治疗轻微型肝性脑病的荟萃分析 |
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| 引用本文： | 汤绍辉,王旷靖,吴小娟,张嫚嫚.益生菌制剂治疗轻微型肝性脑病的荟萃分析[J].世界华人消化杂志,2011(24). |
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| 作者姓名： | 汤绍辉 王旷靖 吴小娟 张嫚嫚 |
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| 作者单位： | 暨南大学附属第一医院消化内科; |
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| 摘 要： | 目的:评价益生菌制剂治疗轻微型肝性脑病(minimal hepatic encephalopathy,MHE)的疗效.方法:检索PubMed、EMBASE、WebofScience、The Cochrane Central Register of Controlled Trials、中国期刊全文数据库、中国科技期刊数据库(维普)、万方数字化期刊全文数据库等关于益生菌制剂治疗MHE的临床随机对照试验(RCT),使用Cochrane图书馆提供的Review Manager4.3软件对入选试验进行荟萃分析.结果:共9项试验满足纳入标准而入选本研究,荟萃分析表明:与对照组相比,益生菌制剂可明显缩短数字连接试验(NCT)反应时间(WMD=13.60,95%CI:1.53-25.66,P=0.03),有效降低血氨水平(SMD=0.98,95%CI:0.25-1.71,P=0.008),减轻内毒素血症(SMD=1.03,95%CI:0.65-1.42,P<0.00001),改善ALT水平(WMD=11.72,95%CI:5.57-17.88,P=0.0002),并降低临床肝性脑病的发生率(RR=0.15,95%CI:0.0...
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| 关 键 词： | 益生菌 轻微型肝性脑病 Meta分析 |
Efficacy of probiotics in the treatment of minimal hepatic encephalopathy:a metaanalysis |
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| Shao-Hui Tang,Kuang-Jing Wang,Xiao-Juan Wu,ManMan Zhang.Efficacy of probiotics in the treatment of minimal hepatic encephalopathy:a metaanalysis[J].World Chinese Journal of Digestology,2011(24). |
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| Authors: | Shao-Hui Tang Kuang-Jing Wang Xiao-Juan Wu ManMan Zhang |
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| Institution: | Shao-Hui Tang,Kuang-Jing Wang,Xiao-Juan Wu,ManMan Zhang,Department of Gastroenterology,the First Affiliated Hospital of Jinan University,Guangzhou 510632,Guangdong Province,China |
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| Abstract: | AIM:To evaluate the efficacy of probiotics in the treatment of minimal hepatic encephalopathy.METHODS:PUBMED,EMBASE,Web of Science,The Cochrane Central Register of Controlled Trials,Chinese Journals Full-text Database,Chinese Biomedical Database and Wan Fang Digital Journal Full-text database were searched to retrieve randomized controlled trials evaluating the eff icacy of probiotics in the treatment of minimal hepatic encephalopathy.Statistical analysis was performed using Review Manager 4.3.RESULTS:Nine ... |
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| Keywords: | Probiotics Minimal hepatic encephalopathy Meta-analysis |
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