| 脱氧胆酸溶液灌肠对大鼠内脏敏感性及脊髓c-fos mRNA表达的影响 |
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| 引用本文： | 王劲松,余保平,胡柳丹,张丽静,田亭亭.脱氧胆酸溶液灌肠对大鼠内脏敏感性及脊髓c-fos mRNA表达的影响[J].世界华人消化杂志,2011(25):2629-2636. |
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| 作者姓名： | 王劲松 余保平 胡柳丹 张丽静 田亭亭 |
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| 作者单位： | 武汉大学人民医院消化内科; |
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| 基金项目： | 中央高校基本科研业务费专项基金资助项目,No.20103020101000200~~ |
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| 摘 要： | 目的:研究脱氧胆酸溶液灌肠对大鼠结肠敏感性和脊髓背根神经节上c-los mRNA表达的影响.方法:以脱氧胆酸溶液连续灌肠3d建立大鼠炎症后慢性内脏痛觉过敏模型,在灌肠前及灌肠后第1,2,3,4周采用结直肠扩张法(CRD)测定腹壁回撤反射(AWR)评分和内脏感觉压力阈值,然后处死大鼠,取出远端结肠组织,行髓过氧化物酶(M...
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| 关 键 词： | 脱氧胆酸 炎症后肠易激综合征 内脏高敏感 c-fos 结直肠扩张 SD大鼠 |
Rectal instillation of deoxycholic acid solution enhances visceral hypersensitivity and up-regulates c-fos mRNA expression in the spinal dorsal horn in rats |
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| Jing-Song Wang,Bao-Ping Yu,Liu-Dan Hu,Li-Jing Zhang,Ting-Ting Tian.Rectal instillation of deoxycholic acid solution enhances visceral hypersensitivity and up-regulates c-fos mRNA expression in the spinal dorsal horn in rats[J].World Chinese Journal of Digestology,2011(25):2629-2636. |
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| Authors: | Jing-Song Wang Bao-Ping Yu Liu-Dan Hu Li-Jing Zhang Ting-Ting Tian |
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| Institution: | Jing-Song Wang,Bao-Ping Yu,Liu-Dan Hu,Li-Jing Zhang,Ting-Ting Tian,Department of Gastroenterology,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei Province,China |
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| Abstract: | AIM: To investigate the effect of rectal instillation of deoxycholic acid solution (DAS) on colorectal visceral sensitivity and the expression of c-fos mRNA in the spinal dorsal horn in rats. METHODS: Rat models were established by giving a rectal perfusion of DSA for 3 days. Rectal distention test was performed to examine rectal sensitivity using AWR score and pressure threshold before and after treatment (1, 2, 3 and 4 wk). The distal colon was used for myeloperoxidase (MPO) assay, and histological examin... |
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| Keywords: | Deoxycholic acid Post-inflammatory irritable bowel syndrome Visceral hypersensitivity C-fos Colorectal distension SD rats |
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