| EZH2在肝癌发生发展中功能的研究进展 |
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| 引用本文： | 张莹莹,周晓巍,黄培堂.EZH2在肝癌发生发展中功能的研究进展[J].世界华人消化杂志,2011(30):3137-3142. |
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| 作者姓名： | 张莹莹 周晓巍 黄培堂 |
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| 作者单位： | 中国人民解放军军事医学科学院生物工程研究所; |
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| 基金项目： | 艾滋病和病毒性肝炎等重大传染病防治国家重大基金资助项目,No.2008ZX10002-021~~ |
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| 摘 要： | 多种因素引起的原癌基因激活和抑癌基因失活是导致肝癌发生发展的主要原因.EZH2是新近发现的具有组蛋白甲基转移酶活性的癌相关基因,主要通过催化H3K27me3修饰介导基因沉默,参与X染色体失活、细胞分化和胚胎发育调节.近来发现,EZH2在多种机制调节下在肝癌组织中过度表达,通过多种机制调控其下游基因异常表达,从而参与肝癌...
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| 关 键 词： | 肝癌 EZH2 组蛋白甲基转移酶 H3K27mer3 基因沉默 |
Progress in understanding the role of EZH2 in the pathogenesis of hepatocellular carcinoma |
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| Ying-Ying Zhang,Xiao-Wei Zhou,Pei-Tang Huang Institute of Biotechnology,Academy of Military Medical Science,Chinese PLA,Beijing ,China.Progress in understanding the role of EZH2 in the pathogenesis of hepatocellular carcinoma[J].World Chinese Journal of Digestology,2011(30):3137-3142. |
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| Authors: | Ying-Ying Zhang Xiao-Wei Zhou Pei-Tang Huang Institute of Biotechnology Academy of Military Medical Science Chinese PLA Beijing China |
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| Institution: | Ying-Ying Zhang,Xiao-Wei Zhou,Pei-Tang Huang Institute of Biotechnology,Academy of Military Medical Science,Chinese PLA,Beijing 100071,China |
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| Abstract: | Primary hepatocellular carcinoma (HCC) is one of the most common malignancies, with a multifaceted molecular pathogenesis. The activation of proto-oncogenes and the inactivation of tumor suppressor genes induced by genetic and epigenetic alterations are major mechanisms of hepatocarcinogenesis. The Polycomb-group gene EZH2 is a newly identified oncogene with gene silencing function, which is mediated by intrinsic histone methyltransferase activity for trimethylation of histone h3 lysine 27 (H3K27me3) and in... |
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| Keywords: | Hepatocellular carcinoma EZH2 Histone methyltransferase H3K27me3 Gene silencing |
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