| 8d与10d序贯疗法根除幽门螺杆菌的疗效比较 |
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| 引用本文： | 张杰,段和力,汪海涛.8d与10d序贯疗法根除幽门螺杆菌的疗效比较[J].世界华人消化杂志,2011(30). |
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| 作者姓名： | 张杰 段和力 汪海涛 |
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| 作者单位： | 河北联合大学附属开滦医院消化科; |
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| 摘 要： | 目的:比较雷贝拉唑、阿莫西林、克拉霉素、奥硝唑组成的8d与10d序贯疗法根除幽门螺杆菌(H.pylori)的疗效.方法:将经胃镜检查确诊为慢性胃炎和消化性溃疡,且H.pylori阳性的217例患者随机分为2组,8d组(n=104)方案:前4d,雷贝拉唑+阿莫西林;后4d,雷贝拉唑+克拉霉素+奥硝唑.10d组(n=113)方案:前5d,雷贝拉唑+阿莫西林;后5d,雷贝拉唑+克拉霉素+奥硝唑.根除治疗后复查14C-尿素呼气试验,比较两组H.pylori根除率.结果:8d组和10d组H.pyloriITT根除率分别为89.3%和91.2%,PP根除率分别为92.0%和93.7%.两种分析方法比较两组的根除率差异均无统计学意义(P>0.05),但8d序贯疗法降低了成本-效果比,减轻了患者的经济负担.两种方案症状缓解率及不良反应发生率的差异无统计学意义(P>0.05).结论:8d序贯疗法可以获得较高的H.pylori根除率和症状缓解率,且经济、安全,是一种可供选择的一线治疗方案.
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| 关 键 词： | 序贯疗法 幽门螺杆菌 根除率 |
Eff icacy of 8-day versus 10-day sequential therapy for Helicobacter pylori eradication |
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| Jie Zhang,He-Li Duan,Hai-Tao Wang.Eff icacy of 8-day versus 10-day sequential therapy for Helicobacter pylori eradication[J].World Chinese Journal of Digestology,2011(30). |
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| Authors: | Jie Zhang He-Li Duan Hai-Tao Wang |
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| Institution: | Jie Zhang,He-Li Duan,Hai-Tao Wang,Department of Gastroenterology,the Affiliated Kailuan Hospital of Hebei United University,Tangshan 063000,Hebei Province,China |
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| Abstract: | AIM: To compare the efficacy of 8-day versus 10-day sequential therapy in the eradication of Helicobacter pylori (H.pylori) infection. METHODS: Two hundred and seventeen patients with H.pylori infection who had peptic ulcer or chronic gastritis were randomly divided into two groups: 8-d group (n = 103, received rabeprazole 10 mg plus amoxicillin 1.0 g for 4 days, and rabeprazole 10 mg plus clarithromycin 500 mg and ornidazole 500 mg for another 4 days) and 10-d group (n = 114, received rabeprazole 10 mg plu... |
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| Keywords: | Sequential therapy Helicobacter pylori Eradication rate |
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