| 瑞香狼毒药效组分对裸鼠肝癌移植瘤的抑制及其机制 |
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| 引用本文： | 潘国凤,杨庆,刘安,朱晓新. 瑞香狼毒药效组分对裸鼠肝癌移植瘤的抑制及其机制[J]. 世界华人消化杂志, 2011, 0(26) |
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| 作者姓名： | 潘国凤 杨庆 刘安 朱晓新 |
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| 作者单位： | 首都医科大学附属北京世纪坛医院;中国中医科学院中药研究所; |
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| 基金项目： | 科技部国际科技合作计划基金资助项目,No.2005DFA31000~~ |
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| 摘 要： | 目的:评价瑞香狼毒药效组分抑制人肝癌细胞株BEL-7402裸鼠皮下移植瘤作用的强度,并探讨其机制.方法:建立人肝癌BEL-7402裸小鼠皮下移植瘤模型研究瑞香狼毒药效组分Zp1111抗肿瘤作用与对荷瘤裸鼠体质量与免疫器官的影响,免疫组织化学法检测用药前后BEL-7402皮下移植瘤组织Bcl-2与Bax阳性表达的变化.结果:Zp1111对裸小鼠皮下移植瘤BEL-7402具有较强的抑制作用,187.5mg/kg、250mg/kg(折合成生药量)剂量时对移植瘤的相对肿瘤增殖率T/C小于60%;该组分能显著上调BEL-7402移植瘤组织Bax基因的表达,但对Bcl-2的表达影响较弱.结论:瑞香狼毒药效组分在体内对人肝癌细胞BEL-7402裸鼠移植瘤具有较强的抑制作用并呈现一定的剂量依赖关系,该组分具有一定的诱导凋亡作用,可能与上调Bax有关.
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| 关 键 词： | 肝肿瘤 瑞香狼毒 细胞凋亡 Bcl-2 Bax |
Antitumor activity of active components alignment isolated from Stellera chamaejasme L.in nude mice bearing subcutaneous BEL-7402 hepatoma |
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| Guo-Feng Pan,Beijing Shijitan Hospital Affiliated to Capital Medical University,Beijing ,China Qing Yang,An Liu,Xiao-Xin Zhu. Antitumor activity of active components alignment isolated from Stellera chamaejasme L.in nude mice bearing subcutaneous BEL-7402 hepatoma[J]. World Chinese Journal of Digestology, 2011, 0(26) |
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| Authors: | Guo-Feng Pan Beijing Shijitan Hospital Affiliated to Capital Medical University Beijing China Qing Yang An Liu Xiao-Xin Zhu |
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| Affiliation: | Guo-Feng Pan,Beijing Shijitan Hospital Affiliated to Capital Medical University,Beijing 100038,China Qing Yang,An Liu,Xiao-Xin Zhu,Institute of Chinese Materia Medica of China Academy of Chinese Medical Sciences,Beijing 100700,China |
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| Abstract: | AIM:To assess the antitumor activity of the effective extracts of S.chamaejasme L.(ScL) in a murine model of hepatocellular carcinoma and to explore the possible mechanisms involved.METHODS:A tumor transplantation model was generated in nude mice to study the antitumor activity of the active components alignment Zp1111 in vivo.Immunohistochemistry(IHC) was employed to investigate the expression of Bcl-2 and Bax in tumor tissue.RESULTS:Zp1111 exhibited strong antitumoractivity in BEL7402-bearing nude mice,wi... |
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| Keywords: | Hepatocellular carcinoma Stellera chamaejasme L. Cell apoptosis Bcl-2 Bax |
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