| 模拟失重对大鼠实验性胃溃疡愈合的影响 |
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| 引用本文： | 张雯,李静,韩全利,陈英,唐合兰,杜斌,杨春敏. 模拟失重对大鼠实验性胃溃疡愈合的影响[J]. 世界华人消化杂志, 2011, 0(27) |
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| 作者姓名： | 张雯 李静 韩全利 陈英 唐合兰 杜斌 杨春敏 |
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| 作者单位： | 安徽医科大学中国人民解放军空军总医院临床学院;中国人民解放军空军总医院东楼消化科; |
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| 基金项目： | 中国人民解放军全军十一五科技攻关基金资助项目,No.08G045~~ |
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| 摘 要： | 目的:探讨模拟失重对乙酸诱导的大鼠实验性胃溃疡愈合的影响及可能机制.方法:32只SD大鼠随机分为4组,即尾部悬吊7d组、尾部悬吊14d组和相应的同步对照组.采用乙酸烧灼法制备大鼠慢性胃溃疡模型,造模后第3天悬吊组大鼠采用尾悬吊法建立模拟失重动物模型.游标卡尺检测胃溃疡面积,电镜下观察再生黏膜结构,放免法检测胃液EGF含量,观察大鼠胃溃疡愈合分期.结果:与对照7d组相比,悬吊7d组大鼠溃疡面积明显增大(6.0mm2±1.7mm2vs2.2mm2±0.7mm2,t=5.661,P<0.01),溃疡分期明显降低(χ2=12.771,P<0.01);与对照14d组相比,悬吊14d组溃疡面积明显增大(3.0mm2±1.2mm2vs1.1mm2±0.4mm2,t=4.233,P<0.01),胃液EGF含量明显增高(0.155ng/mL±0.052ng/mLvs0.103ng/mL±0.019ng/mL,t=2.635,P<0.05);与悬吊7d组比较,悬吊14d组溃疡面积明显减小(3.0mm2±1.2mm2vs6.0mm2±1.7mm2,t=3.805,P<0.01),胃液EGF含量明显降低(0.155ng/mL±0.0...
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| 关 键 词： | 模拟失重 实验性胃溃疡 尾部悬吊 再生黏膜 表皮生长因子 |
Effect of simulated weightlessness on the healing of experimental gastric ulcer in rats |
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| Wen Zhang,Chun-min Yang,Anhui Medical University Affiliated General Hospital of Air Force of Chinese PLA,Beijing ,China Jing Li,Quan-Li Han,Ying Chen,He-Lan Tang,Bin Du. Effect of simulated weightlessness on the healing of experimental gastric ulcer in rats[J]. World Chinese Journal of Digestology, 2011, 0(27) |
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| Authors: | Wen Zhang Chun-min Yang Anhui Medical University Affiliated General Hospital of Air Force of Chinese PLA Beijing China Jing Li Quan-Li Han Ying Chen He-Lan Tang Bin Du |
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| Affiliation: | Wen Zhang,Chun-min Yang,Anhui Medical University Affiliated General Hospital of Air Force of Chinese PLA,Beijing 100142,China Jing Li,Quan-Li Han,Ying Chen,He-Lan Tang,Bin Du,Department of Gastroenterology,East Building,Air Force General Hospital of Chinese PLA,China |
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| Abstract: | AIM: To investigate the effect of simulated weightlessness on the healing of acetic acid-induced experimental gastric ulcer in rats and to explore the potential mechanisms involved. METHODS: Thirty-two SD rats were randomly and equally divided into four groups: 7 d tail suspension group, 7 d control group,14 d tail suspension, and 14 d control group. Gastric ulcer was induced in rats with acetic acid. Tail suspension was used to simulate the weightlessness condition 3 days after ulcer induction. The gastric... |
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| Keywords: | Simulated weightlessness Experimental gastric ulcer Tail suspension Ultrastructure Epidermal growth factor |
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