| 结直肠癌肝转移的预后因素 |
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| 引用本文： | 王科伟,范海银,孔凡民,董明. 结直肠癌肝转移的预后因素[J]. 世界华人消化杂志, 2011, 0(29) |
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| 作者姓名： | 王科伟 范海银 孔凡民 董明 |
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| 作者单位： | 中国医科大学附属第一医院; |
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| 摘 要： | 目的:评价结直肠癌肝转移的临床预后因素及治疗方案对预后的影响.方法:收集71例结直肠癌肝转移患者的临床资料及预后情况,用Kaplan-Meier生存分析及Log-rank检验进行单因素分析,将有统计学意义的预后因素纳入Cox回归模型进行多因素分析.结果:Kaplan-Meier单因素分析及Log-rank检验显示,肝转移灶最大直径、有无区域淋巴结转移及诊断肝转移时碱性磷酸酶(ALP)最高值3个因素对其预后影响有显著意义;将这3个预后因素纳入Cox回归多因素分析显示,有无区域淋巴结转移、诊断肝转移时ALP最高值是结直肠癌肝转移的独立预后因素.全组3种治疗方式比较差别无统计学意义,但对手术切除组和化疗组两组进行比较,差异有统计学意义(P<0.05),而局部治疗组和手术组之间,局部治疗组和化疗组之间差别无统计学意义.结论:肝转移灶最大直径、原发病灶有无区域淋巴结转移、诊断肝转移时最高ALP值是结直肠癌肝转移患者的预后因素;肝转移灶最大直径越小、无区域淋巴结转移、诊断肝转移时最高ALP值正常的患者预后越好;手术切除联合化疗目前是结直肠癌肝转移的首选治疗方案,可获得较好的远期生存.
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| 关 键 词： | 结直肠癌 肝转移 预后 手术治疗 |
Analysis of prognostic factors for colorectal liver metastases |
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| Ke-Wei Wang,Hai-Yin Fan,Fan-Min Kong,Ming Dong Ke-Wei Wang,Ming Dong. Analysis of prognostic factors for colorectal liver metastases[J]. World Chinese Journal of Digestology, 2011, 0(29) |
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| Authors: | Ke-Wei Wang Hai-Yin Fan Fan-Min Kong Ming Dong Ke-Wei Wang Ming Dong |
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| Affiliation: | Ke-Wei Wang,Hai-Yin Fan,Fan-Min Kong,Ming Dong Ke-Wei Wang,Ming Dong,Department of Gastrointestinal Surgery,the First Hospital of China Medical University,Shenyang 110001,Liaoning Province,China |
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| Abstract: | AIM: To evaluate the clinical prognostic factors for colorectal liver metastases and to analyze the impact of different treatments on prognosis. METHODS: The clinical and prognostic data for 71 patients with colorectal liver metastases were analyzed. Univariate analysis was performed using the Kaplan-Meier method and Log-rank test to find significant prognostic factors, while multivariate analysis was performed using the Cox regression model. RESULTS: Univariate analysis showed that the maximum diameter of ... |
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| Keywords: | Colorectal cancer Liver metastasis Prognosis Surgical resection |
| 本文献已被 CNKI 等数据库收录！ |
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