| 全基因组关联分析在消化系肿瘤中的研究进展 |
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| 引用本文： | 马进,陈云昭,李锋. 全基因组关联分析在消化系肿瘤中的研究进展[J]. 世界华人消化杂志, 2011, 0(33) |
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| 作者姓名： | 马进 陈云昭 李锋 |
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| 作者单位： | 新疆地方与民族高发病教育部重点实验室/石河子大学医学院病理教研室; |
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| 基金项目： | 国际科技合作与交流专项基金资助项目,No.2010DFB34100; “十一五”国家科技支撑计划基金资助项目,No.2009BAI82B03; 国家自然科学基金资助项目,No.81160301 |
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| 摘 要： | 全基因组关联分析(genome-wide association study,GWAS)是应用人类基因组中单核苷酸多态性(single nucleotide polymorphism,SNP)为标记进行分析,以期发现影响复杂性疾病发生的遗传特征的一种新策略.因其可在全基因组范围内进行整体研究,能够一次性对疾病与基因的关联进行轮廓性概览,所以在过去的5年中,全基因组关联研究方法已被证明是研究复杂疾病一种有效手段.近年,各国科学家运用全基因组关联分析在人类肿瘤,特别是在消化系肿瘤的研究中取得了一系列重要的研究成果,本文将综述消化系肿瘤GWAS研究进展,并展望GWAS所面临的挑战及可能的解决策略.
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| 关 键 词： | 全基因组关联分析 食管癌 胃癌 结直肠癌 |
Progress in genome-wide association study of digestive tract cancers |
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| Jin Ma,Yun-Zhao Chen,Feng Li,Key Laboratory of Xinjiang Endemic , Ethnic Disease. Progress in genome-wide association study of digestive tract cancers[J]. World Chinese Journal of Digestology, 2011, 0(33) |
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| Authors: | Jin Ma Yun-Zhao Chen Feng Li Key Laboratory of Xinjiang Endemic Ethnic Disease |
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| Affiliation: | Jin Ma,Yun-Zhao Chen,Feng Li,Key Laboratory of Xinjiang Endemic and Ethnic Disease,Department of Pathology,Medical College of Shihezi University,Shihezi 832002,Xinjiang Uygur Autonomous Region,China |
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| Abstract: | Genome-wide association analysis is a new strategy for discovering genetic characteristics affecting the development of complex diseases, which uses human genome single nucleotide polymorphisms (SNPs) as markers. Using high-throughput techniques, genome-wide association analysis permits to genotype whole-genome SNPs and to explore their association with complex disease at one time. Over the past 5 years, genome-wide association studies have been proven to be a powerful approach for screening the susceptibil... |
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| Keywords: | Genome-wide association study Esophageal cancer Gastric cancer Colorectal cancer |
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