血清高密度脂蛋白及其亚型胆固醇与肝功能关系的探讨

本文了测定了45例失代偿期肝硬化及24例慢性活动性肝炎（包括早期肝硬化）患者血胆固醇含量，血甘油三酯和高密度脂蛋白及其亚型胆固醇含量，结果表明失代偿期肝硬化患者血清高密度脂蛋白胆固醇（HDLch)，高密度脂蛋白3胆固醇（HDL3ch），血总胆固醇（Tc)与正常对照组及慢活肝组之间存在非常显著的差异（P＜0．001），而其高密度脂蛋白2胆固醇与后二者尽管也存在显著差异，但其敏感性较差（P＜0．01），提示HDLch,HDL3ch可以作为判断肝功能状态敏感的指标。

Relationship Between Hepatic Function and Serum High Density Lipoprotein and its Subtypes cholesterol

In this paper, serum total cholesterol (TC), triglyceride(TG), high density lipoprotein (HDL) and its subtypes cholesterol (HDLch, HDL2ch, and HDL3ch)were measured in 45 cases of decompensated hepatocirrhosis,24 cases of chronic active hepatitis(including a few cases of early cirrhosis)and 2 5 cases of normal control. The results showed that HDLch, HDL3ch and Tc were greatly significantly lower in decompensated cirrhosis than those in normal control and chronic active hepatitis(P<0. 001).HDL2Chwas also significantly lower in decompensated cirrhosis but its sensitivity was relatively low(P<0.01).There was no significant difference between chronic active hepatitis and normal control concerning Tc, HDLch, HDL2ch and HDL3ch. Our results indicated that HDLch and HDL3ch could serve as reliable and sensitive markers of the functional damage of liver while Tc could also reflect that when the effect of diet was excluded.