加味没竭片对原发性痛经患者经期血浆催产素的影响

目的：观察加味没竭片对原发性痛经患者经期血浆催产素(oxytocin，OT)的影响，探讨其治疗原发性痛经的作用机制。方法：将原发性痛经患者63例，随机分为加味没竭片治疗组(加味没竭片组，33例)和月月舒7中剂对照组(月月舒组，30例)，并设健康对照组16名。观察治疗前后患者经期血浆OT含量变化。结果：原发性痛经患者OT水平明显高于健康对照组(P<0．01)，患者血浆OT含量与疼痛程度呈显著正相关(r=0．738，P<0．01)；治疗后加味没竭片组OT含量显著下降(P<0．01)，优于月月舒组(P<0．01)。结论：加味没竭片能降低原发性痛经患者经期血浆催产素含量。

Effect of Jiawei Mojie Tablet on Plasma Oxytocin Level in Patients with Primary Dysmenorrhea in Menstrual Period

Objective: To investigate the therapeutic mechanism of Jiawei Mojie Tablet (JMT) in treating primary dysmenorrhea (PD) by observing its effect on plasma oxytocin (OT) level in patients in menstrual period. Methods: Sixty three patients with PD enrolled in the study were randomly divided into the JMT group (n=33) and the control Group (n=30, treated with Yueyueshu Granule) to observe the change of OT level in the menstrual period before and after treatment. Results: OT level in patients with PD was obviously higher than that in healthy subjects (P<0 01), and was positively correlated with the degree of pain (r=0.738, P<0 01). OT level reduced significantly after treatment (P<0 01), the reduction was more significant in the JMT group than that in the control group (P<0 01). Conclusion: JMT could reduce the OT level in menstrual period.