| 多中心肾癌发生机制探讨 |
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| 引用本文： | 刘广华,李汉忠,夏溟,纪志刚,谢毅.多中心肾癌发生机制探讨[J].临床泌尿外科杂志,2006,21(8):579-581. |
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| 作者姓名： | 刘广华 李汉忠 夏溟 纪志刚 谢毅 |
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| 作者单位： | 中国医学科学院,中国协和医科大学,北京协和医院泌尿外科,北京,100730;中国医学科学院,中国协和医科大学,北京协和医院泌尿外科,北京,100730;中国医学科学院,中国协和医科大学,北京协和医院泌尿外科,北京,100730;中国医学科学院,中国协和医科大学,北京协和医院泌尿外科,北京,100730;中国医学科学院,中国协和医科大学,北京协和医院泌尿外科,北京,100730 |
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| 摘 要： | 目的:探讨多中心肾癌的发生机制及影响因素,为肾癌肾部分切除术寻找依据。方法:对42例肾癌根治标本进行薄切后行病理检查,同时行增殖细胞核抗原(PCNA)、微血管密度(MVD)和血管内皮生长因子(VEGF)三种免疫组化检查。结果:42例肾癌中,多中心肾癌6例,血管瘤栓比例为83.3%,PCNA、MVD及VEGF表达分别为26.8%、84.02、2.35;单中心肾癌的血管瘤栓比为11.1%,三种免疫组化检查分别为26.1%、56.03、1.46。结论:PCNA、MVD及VEGF高表达是多中心肾癌的重要影响因素,多中心肾癌可能是肿瘤侵入微血管造成肾内播散的结果。
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| 关 键 词： | 肾癌 多中心性 增殖细胞核抗原 微血管密度 血管内皮生长因子 |
| 文章编号： | 1001-1420(2006)08-0579-03 |
| 收稿时间： | 10 28 2005 12:00AM |
| 修稿时间： | 2005年10月28 |
Analysis of mechanism to multifocal renal cell carcinoma |
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| LIU Guanghua,LI Hanzhong,XIA Ming,JI Zhigang,XIE Yi.Analysis of mechanism to multifocal renal cell carcinoma[J].Journal of Clinical Urology,2006,21(8):579-581. |
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| Authors: | LIU Guanghua LI Hanzhong XIA Ming JI Zhigang XIE Yi |
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| Institution: | Department of Urology, Peking Union Medical Collage Hospital, Beijing, 100730, China |
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| Abstract: | Objective:To study the genesis and influential factors of multifocal renal cell carcinoma for the nephron sparing surgery.Methods:42 kidneys from radical nephrctomy for RCC are sectioned, then to take pathological and immunochemical examination including PCNA, MVD and VEGF.Results:There are 6 multifocal renal cell carcinoma in 42 cases. Microvessel of tumors are invaded in 83.3% of multifocal renal cell carcinoma while in 11.1% of unifocal renal cell carcinoma. The expression of PCNA, MVD and VEGF is 26.8%, 84.02, 2.35 respectively in multifocal renal cell carcinoma while 26.1%, 56.03, 1.46 respectively in unifocal renal cell carcinoma.Conclusions:Invaded microvessel by tumor tissue , high expression of MVD and VEGF are the important factors of multifocal renal cell carcinoma, it may be the result of tumor invading into microvessel and dispersion in the renal parenchyma. |
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| Keywords: | Renal cell carcinoma multicentricity PCNA MVD VEGF |
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