Effect of Mifepristone on Transforming Growth Factor-β and its Receptor Transcription in Decidua, Villi and Serum Tumor Necrosis Factor -α Level in Early Human Gestation
Li-ping JIN1,Da-jin LI1,Jing-yu SHAO2,Song-guo ZHENG3,Xue-zhe WU21. Laboratory of Reproductive Immunology,Institute of Obstetrics and Gynecology,Fudan University,Shanghai 200011,China2. Shanghai First Maternity & Infant Health Hospital,Shanghai 200040,China3. Laboratory of Molecular Biology,Tumor Hospital,Fudan University,Shanghai 200032,China
摘 要:
Mifepristone is a progesterone antagonist which acts at the level of the receptor. Itbinds the progesterone receptor with a high affinity and antagonises progesterone biologicalaction. It has been applied in clinical use for multiple therapeutic purposes. In obstetrics andgynecology, mifepristone has been effective in medical termination of pregnancy in the firsttrimester. Mifepristone followed approximately 48 h later by a prostaglandin analog hasbeen reported to effect complete abortion in 9…