The effects of trapidil and propranolol on platelet aggregation and prostacycline-thromboxane balance following acute myocardial infarction in rabbits |
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Authors: | Lu Xiang Ling Hong Dong Chuan-ren Ouyang Jing-ping |
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Institution: | (1) The First Affiliated Hospital, Nanjing Medical College, Nanjing;(2) Department of Pathophysiology, Hubei Medical College, Wuhan |
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Abstract: | Summary Changes in infarct size, platelet aggregation, and plasma 6-k-PGF1 α and thromboxane B2 levels in the coronary sinus and arterial blood were observed in rabbits following acute myocardial infarction with or without
trapidil or propranolol treatment. It was found that platelet aggregation, thromboxane B2 and 6-k-PGF1 α were elevated significantly in the control group 6 h after coronary ligation. These changes were inhibited by trapidil as
well as propranolol, either of which could limit infarct size remarkably. |
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Keywords: | acute myocardial infarction platelet aggregation thromboxane trapidil propranolol |
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