Nano-Ag inhibiting action potential independent glutamatergic synaptic transmission but increasing excitability in rat CA1 pyramidal neurons |
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Authors: | Liu Zhaowei Zhang Tao Ren Guogang Yang Zhuo |
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Affiliation: | College of Medicine, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin, P. R. China. |
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Abstract: | The aim of this study was to investigate the actions of silver nanoparticles (nano-Ag) on glutamatergic synaptic transmission and excitability in hippocampal CA1 pyramidal neurons with whole cell patch technique. The amplitude of miniature excitatory postsynaptic currents (mEPSCs) was inhibited by silver nano-particles (nano-Ag) (10?? g/ml and 10?? g/ml), but the amplitude and frequency of spontaneous excitatory postsynaptic currents (sEPSCs) were increased by nano-Ag treatment (10?? g/ml and 10?? g/ml). Furthermore, nano-Ag (10?? g/ml and 10?? g/ml) increased the spontaneous network activity. These results provide further insights into the underlying mechanisms responsible for the effects of nano-Ag on central nervous system (CNS). |
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