| 美托洛尔对急性心肌梗死心率变异性及恶性心律失常的影响 |
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| 引用本文： | 石翔. 美托洛尔对急性心肌梗死心率变异性及恶性心律失常的影响[J]. 临床心血管病杂志, 2001, 17(4): 164-165 |
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| 作者姓名： | 石翔 |
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| 作者单位： | 湘西自治州人民医院心内科 |
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| 摘 要： | 目的探讨美托洛尔对急性心肌梗死(AMI)后心率变异性(HRV)及恶性心律失常(MVA)事件的影响。方法将77例分为美托洛尔组(40例)及对照组(37例)，美托洛尔组在常规治疗基础上给予美托洛尔6.25～12.5mg，bid，以后根据病情渐加量到25～50mg，bid；对照组仅常规治疗，并分别测定入院后第1天、第7天、0.5年、1年时48h动态心电图，常规进行HRV分析，并同时观察各阶段MVA发生率。结果1周内两组HRV及MVA变化差异无显著性意义，但美托洛尔组MVA事件有减少趋势，0.5年后美托洛尔组HRV显著改善(P＜0.01），MVA事件发生率显著低于对照组(P＜0.01）。结论美托洛尔能有效改善AMI后患者HRV，降低MVA发生率，但此种改变在长时间治疗后明显。
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| 关 键 词： | 心肌梗死；美托洛尔；心率变异性；心律失常 |
| 文章编号： | 1001-1439(2001)04－0164-02 |
| 修稿时间： | 2000-11-27 |
Influence of metoprolol on heart rate variability and malignantventricular arrhythmia in acute myocardial infarction |
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| Shi Xiang. Influence of metoprolol on heart rate variability and malignantventricular arrhythmia in acute myocardial infarction[J]. Journal of Clinical Cardiology, 2001, 17(4): 164-165 |
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| Authors: | Shi Xiang |
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| Abstract: | Objective:To discover the effect of metoprolol on heart rate variability (HRV) and malignant ventricular arrhythmia (MVA) in acute myocardial infarction. Method: Seventy-seven patients were randomly divided into 2 groups :metoprolol group ( n = 40) and control group ( n＝ 37). The metoprolol group were given metoprolol 12.5～50 mg twice a day. Then the HRV and MVA events in each period (1 day,7 day,6 month and 1 year) in two groups were measured and compared. Result:The HRV and MVA events were of no significant changes in both groups in a week. After six month, the MVA events were remarkably decreased in metoprolol group (P ＜ 0. 01). Conclusion.. Metoprolol may improve the HRV and reduce the MVA events in acute myocardial infarction. |
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| Keywords: | Myocardial infarction Metoprolol Heart rate variability Arrhythmia |
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