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Acute ammonia treatment in vitro and in vivo inhibits the synthesis of a neuroprotectant kynurenic acid in rat cerebral cortical slices |
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| Authors: | Tomasz Saran Wojciech Hilgier Tomasz Kocki Ewa M. Urbanska Waldemar A. Turski Jan Albrecht |
| Affiliation: | aDepartment of Pharmacology and Toxicology, Medical University School, Jaczewskiego 8, 20-090 Lublin, Poland;bDepartment of Neurotoxicology, Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland;cDepartment of Clinical Toxicology, Institute of Agricultural Medicine, Jaczewskiego 2, 20-950 Lublin, Poland |
| Abstract: | The synthesis of kynurenic acid (KYNA) from kynurenine was measured in the cerebral cortical slices. In vitro, ammonium acetate at the subtoxic to toxic concentration range from 1 mM to 10 mM dose-dependently inhibited KYNA synthesis (IC50=2.99 mM). Ammonia treatment in vivo decreased KYNA synthesis by 30%. These results suggest that impaired neuroprotection exerted by KYNA might be a potential contributor to the glutamate receptor-mediated aspect of acute ammonia neurotoxicity. |
| Keywords: | Rat brain Ammonia Hyperammonemia Kynurenic acid Excitotoxicity |
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