Co-localization of μ-opioid receptor-like immunoreactivity with substance P-LI, calcitonin gene-related peptide-LI and nitric oxide synthase-LI in vagal and glossopharyngeal afferent neurons of the rat |
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Authors: | Yu-Qiang Ding Jin-Lian Li Bao-Zhen Lü Dan Wang Miao-Li Zhang Ji-Shuo Li |
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Institution: | Department of Anatomy and K.K. Leung Brain Research Center, Fourth Military Medical University, Xi'an 710032, China |
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Abstract: | Co-localization of μ-opioid receptor (MOR)-like immunoreactivity (-LI) with substance P (SP)-LI, calcitonin gene-related peptide (CGRP)-LI and nitric oxide synthase (NOS)-LI in the nodose, petrosal and jugular ganglia was examined in the rat by a double immunofluorescence histochemical method. About 0.6%, 41% and 95% of neurons with MOR-LI, respectively, in the nodose, petrosal and jugular ganglia showed SP-LI; about 2%, 51% and 66% of MOR-like immunoreactive neurons displayed CGRP-LI in the nodose, petrosal and jugular ganglia, respectively. In addition, about 59% of MOR-like immunoreactive neurons in the nodose ganglia displayed NOS-LI, whereas no NOS-LI was detected in the petrosal or jugular ganglion. These data provide evidence for co-localization of MOR-LI with SP-LI, CGRP-LI and NOS-LI in the vagal and glossopharyngeal afferent neurons, and suggest that MOR may regulate the release of SP, CGRP and nitric oxide from the visceral primary afferent terminals in the nucleus of the solitary tract of the rat. |
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Keywords: | μ-Opioid receptor Substance P Calcitonin gene-related peptide Nitric oxide synthase Nodose ganglion Petrosal ganglion Jugular ganglion Coexistence Rat |
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