血浆内皮素对糖尿病并发心血管疾病作用机制探讨

目的 :探讨血浆内皮素在糖尿病并发心血管疾病中的作用。方法 :采用放射免疫分析法测定了34例糖尿病患者 ,2 7例糖尿病并发心血管病患者及 30例正常健康人血浆中的内皮素的含量。结果 :糖尿病组血浆内皮素含量显著高于正常对照组 (p <0 .0 1) ,糖尿病并发心血管病组血浆内皮素含量明显高于糖尿病无并发症组 (p <0 .0 1)。结论 :血浆内皮素在糖尿病并发心血管疾病的过程中起着重要作用 ,可以作为早期发现糖尿病心血管并发症的敏感指标之一

Investigation of Role of Plasma Endothelin in Diabetes Mellitus Patients Complicated with Angiocardiopathy

Objective To study the role of plasma endothelin in diabetes mellitus (DM) patients complicated with angiocardiopathy. Methods Plasma endothelin levels were determined by redioimmunoassay in 34 diabetics, 27 diabetics complicated with angiocardiopathy and in 30 controls. Results Plasma endothelin levels in both diabetic groups were significantly higher than those in normal subjects (p<0.01); plasma endothelin levels in DM patients complicated with angiocardiopathy were significantly higher than those in patients with diabetes only (p<0.01). Conclusion Plasma endothelin was of important role in the pathogenesis of DM complicated with angiocardiopathy and could be used as an early and sensitive marker.