| 6-甲基-4-(1H)-吡啶酮-3-羧酸的制备 |
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| 引用本文： | 李玉娟,王钝,于鑫,许树森. 6-甲基-4-(1H)-吡啶酮-3-羧酸的制备[J]. 沈阳药科大学学报, 2005, 22(1): 17-18 |
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| 作者姓名： | 李玉娟 王钝 于鑫 许树森 |
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| 作者单位： | 1. 哈药集团制药总厂,黑龙江,哈尔滨,150046
2. 沈阳药科大学,制药工程学院,辽宁,沈阳,110016 |
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| 摘 要： | 目的制备 6 甲基 4 (1H) 吡啶酮 3 羧酸。方法以 4 羟基 6 甲基 2 吡喃酮、N ,N 二甲基甲酰胺二甲氧基缩醛为起始原料 ,经两步反应制得目标化合物。结果与结论经熔点测定及1H NMR、MS分析确证目标产物结构 ,总收率为 39 6 % ,高于文献收率
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| 关 键 词： | 4-羟基-6-甲基-2-吡喃酮 6-甲基-4-(1H)-吡啶酮-3-羧酸 合成 |
| 文章编号： | 1006-2858(2005)01-0017-02 |
| 修稿时间： | 2004-04-02 |
Synthesis of 6-methyl-4-(1H)-pyridone-3-carboxylic acid |
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| LI Yu-juan ,WANG Dun ,YU Xin ,XU Shu-seng. Synthesis of 6-methyl-4-(1H)-pyridone-3-carboxylic acid[J]. Journal of Shenyang Pharmaceutical University, 2005, 22(1): 17-18 |
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| Authors: | LI Yu-juan WANG Dun YU Xin XU Shu-seng |
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| Affiliation: | LI Yu-juan 1,WANG Dun 2,YU Xin 2,XU Shu-seng 2 |
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| Abstract: | Objective To prepare 6-methyl-4-(1H)-pyridone-3-carboxylic acid.Methods The target compound was synthesized by two steps with 4-hydroxy-6-methyl-2-pyrone and N,N-dimethylformamide dimethyl acetal as the starting materials.Results and Conclusions The desired product was obtained in overall yield of 39.6% higher than that reported in literature and its structure was confirmed by the melting point, 1H-NMR and MS. |
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| Keywords: | hydroxy-6-methyl-2-pyrone 6-methyl-4-(1H)-pyridone-3-carboxylic acid synthesis |
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