Metabolism-mediated cytotoxicity of chemical carcinogens and non-carcinogens |
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| Authors: | Philip Wiebkin Jeffrey R. Fry James W. Bridges |
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| Affiliation: | 1. Institute of Industrial and Environmental Health and Safety and Department of Biochemistry, University of Surrey, Guildford, Surrey GU2 5XH, England |
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| Abstract: | The results presented in this paper clearly demonstrate that a fibroblast suppression test system incorporating viable hepatocytes can be of value in studying the problems of metabolism-mediated cytotoxicity for those compounds and/or metabolites that are sufficiently stable to traverse cell membranes. The possibility that this test system can be used to distinguish carcinogenic and non-carcinogenic chemicals cannot be resolved at this time, however. |
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| Keywords: | AAF, acetylaminofluorene AC, aminochrysene CPA, cyclophosphamide DBA, dimethylaininoazobenzene DMN, dimethylnitrosamine 4-HAQO, 4-hydroxylaminoquinoline N-oxide 4-NQO, 4-nitroquinoline N-oxide |
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