电针对肝硬化大鼠谷胱甘肽及小肠黏膜形态的影响

目的　探讨针刺治疗肝硬化的机理。方法　用CCL4 将模型组、电针组造成肝硬化模型,并与正常对照,观察肝组织、血清、肠道谷胱甘肽(GSH)含量并定量分析小肠黏膜状态。结果和结论　电针组的上述指标均显著高于模型组(P<0. 01),说明针刺能升高实验性肝硬化大鼠的GSH改善门脉高压所致之胃肠黏膜病(PHE)的肠道瘀血状态,治疗肝硬化;电针组的各项指标却低于正常组(P<0. 01),宜延长针刺疗程和调整穴位配伍作进一步观察。

Influence of Electroacupuncture on Glutathione and the Morphology of Enteric Mucosa in Hepatocirrhosis Rats

Objective To investigate the mechanism by which acupuncture treats hepatocirrhosis.Methods A model of hepatocirrhosis was made with CCL 4.The models were divided into model and electroacupuncture groups and a normal group was established as a control to observe hepatic,serous and intestinal glutathione (GSH) contents and to quantitatively analyze the state of enteric mucosa.Results and Conclusion The above indices were significantly higher in the electroacupuncture group than in the model group(P< 0.01), showing that acupuncture can raise GSH in experimental hepatocirrhosis rats and abate intestinal blood stagnancy in gastrointestinal mucosa disease due to portal hypertension so as to treat hepatocirrhosis.The indices were significantly lower in the electroacupuncture group than in the control group(P<0.01) and therefore the course of acupuncture treatment should be prolonged and point compatibility adjusted for further investigation.