两种临床常用CCB类降压药清晨血压控制情况的比较

目的 观察本院目前常用的两种CCB类降压药苯磺酸氨氯地平与硝苯地平控释片在清晨血压控制方面的疗效异同.方法 选取2013年3月～2014年3月在本院门诊就诊的158例轻、中度原发性高血压患者,按照统一设计的观察指标和分析内容,在征得患者同意后,进行初始信息收集.对资料完整的患者按照服用降压药物的不同分为观察组（n=82）和对照组（n=76）,观察组应用苯磺酸氨氯地平片5 mg,1次/d,对照组应用硝苯地平控释片30 mg,1次/d,分别监测用药后1、4、8周的清晨血压,比较两组患者清晨血压达标情况.结果 治疗1周后对照组血压达标率为32.9％,高于观察组的19.5％,差异有统计学意义（P＜0.05）;治疗4周后观察组血压达标率为46.3％,对照组血压达标率为47.4％,差异无统计学意义（P＞0.05）;治疗8周后观察组血压达标率为65.9％,高于对照组的60.5％,但差异无统计学意义（P＞0.05）.结论 苯磺酸氨氯地平和硝苯地平控释片治疗高血压的效果一致,没有明显差异,但是对于清晨时段血压较高的患者,苯磺酸氨氯地平具有一定优势.

Early-morning blood pressure control comparison by two frequently-used antihypertensive drugs in CCB group in clinic

Objective To observe the effect differences of early-morning blood pressure control by two frequently-used antihypertensive drugs containing levamlodpine besylate tablet and nifedipine controlled release tablet in calcium channel blockers （CCB） group in clinic. Methods 158 patients with mild or moderate primary hypertension visited our outpatient clinic from March 2013 to March 2014 were selected.According to the unified obvervational index and con- tent for analysis,preliminary data were collected after getting agreement from these patients.If patient＇s data was com- plete,he/she would be divided into observation group or control group based on different antihypertensive drugs.In the observation group （n=82）,5 mg levamlodpine besylate tablet was taken once per day,while in the control group （n=76）, 30 mg nifedipine controlled release tablet was taken once per day.Blood pressures in the early morning was monitored 1,4,and 8 weeks after taking tablets respectively.The conditions of early-morning blood pressure reaching the standard in the two groups were compared. Results After one-week treatment,the rate of reaching the standard in control group was 32.9%,higher than 19.5% in observation group,the difference was significant （P〈0.05）.After 4 weeks treatment,the rate of reaching the standard in observation group was 46.3%,and was 47.4% in control group,the difference was not significant （P〉0.05）.After 8 weeks therapy,the rate of reaching the standard in observation group was 65.9%,higher than 60.5% in control group,but the difference was not significant （P〉0.05）. Conclusion The effect on treating hypertension by levamlodpine besylate tablet and nifedipine controlled release tablet doesn＇t display significant difference,but for patients With moderate hypertension in the early morning,levamlodpine besylate tablet still gets some superiorities.