白介素-7与原发性高血压血管内皮生长因子的相关性研究

目的：探讨白介素-7（IL-7）与原发性高血压血管内皮功能改变之间的关系。方法：50例实验组分为高血压病1级组25例，高血压病合并冠心病组25例。另设正常对照组20例。使用酶联免疫吸附法进行各组血清IL-7与血管内皮生长因子（VEGF）浓度测定，同时测定血糖、血脂，比较各组间检测指标的差异。结果：（1）高血压组血清IL-7含量（105．30土15．77）pg／ml及VEGF含量（13．58±3．55）ng／ml均高于正常对照组IL-7含量（70．14±6．45）pg／ml及VEGF含量（2．58±0．66）ng／ml（P均〈0．01）；（2）高血压病合并冠心病组，血清IL-7含量（119．62±6．41）pg／ml与VEGF含量（16．18±2．57）ng／ml，均高于高血压病1级组的IL-7（90．91±4．89）pg／ml与VEGF（6．98±2．25）ng／ml，以及正常对照组（P均〈0．01）；（3）高血压病1级组、高血压合并冠心病组的VEGF水平与IL-7浓度呈正相关（r=0．481，P〈0．05；r=0．558，P〈0．01）结论：血清IL-7水平升高与VEGF水平升高呈正相关，可能参与了原发性高血压的发生、发展。

Relationship between Interleukin-7 and changes of blood vessel endothelial growth factor

Objective： To study the relationship between Interleukin-7 （IL-7） and changes of blood vessel endothelial growth factor （VEGF） in patients with essential hypertension （EH）. Methods： Experiment group （50 subjects） included the hypertension class t patients group （25 subjects） and hypertension complicated coronary artery disease （CAD） group （25 subjects）. Twenty health control subjects were studied. Use the method of enzyme-linked immunoassay to detect the concentration of serum IL-7, VEGF. Blood sugar and blood fat also detected. The detection indexes were compared with each group. Results.. （1） In the hypertension group, serum IL--7 content was （105.30± 15.77） pg/ml and VEGF was （13.58±3.55） ng/ml. While in the health control group, serum IL-7 was （70.14±6.45） pg/ml and VEGF was （2.58±0. 66） ng/ml. So those of hypertension group were higher than those of health control group （P〈0.01）; （2） The serum IL--7 （119.62±6.41） pg/ml and VEGF （16.18±2.57） ng/ml in hypertension complicated CAD group were higher than those of hypertension group serum IL--7 （90.91±4. 89） pg/ml and VEGF （6.98±2.25） ng/ml] and health control group （P〈0.01）. （3） The serum VEGF of hypertension group was positive correlated with IL--7 （r=0. 481, P〈0.05）. The serum VEGF of hypertension complicated CAD group was positive correlated with IL-7 （r=0. 558, P〈0.01）. Conclusion： The serum IL--7 level increases and positive correlates with VEGF in hypertension patients, it suggests that IL-7 and VEGF possibly participate the development of essential hypertension.