Impact of simulated microgravity on microvascular endothelial cell apoptosis |
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Authors: | Kang Chun-Yan Zou Lin Yuan Ming Wang Yang Li Tian-Zhi Zhang Ye Wang Jun-Feng Li Yan Deng Xiao-Wei Liu Chang-Ting |
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Affiliation: | (1) Nanlou Respiratory Diseases Department, Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China;(2) The State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, 100094, People’s Republic of China;(3) Department of Respiratory Diseases, Affiliated Hospital of the Academy of Military Medical Science, Beijing, 100071, People’s Republic of China;(4) Exclusive Medical Care Centre, General Hospital of Chinese People of Armed Police Forces, Beijing, 100039, People’s Republic of China |
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Abstract: | Cardiovascular deconditioning is known to occur in astronauts exposed to microgravity. Endothelial dysfunction at microcirculatory sites might contribute to cardiovascular deconditioning induced by weightlessness. Recent studies have reported changes in the morphology and gene expression of endothelial cells exposed to conditions of simulated microgravity. The present study was aimed at examining the effects of microgravity on the apoptosis of microvascular endothelial cells and the mechanism underlying these effects. We simulated a microgravity environment and found that microgravity induced microvascular endothelial cell apoptosis and that this effect was correlated with the downregulation of the PI3K/Akt pathway, increased expression of NF-κB, and depolymerization of F-actin. These findings may provide important insights into the origin of the adverse physiological changes occurring due to exposure to microgravity conditions. |
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