New group of class III antiarrhythmic drugs: piperid-4-ylethane derivatives |
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| Authors: | R. G. Glushkov S. D. Yuzhakov A. I. L’vov G. P. Zhikhareva N. K. Davydova O. S. Sizova V. V. Asnina E. N. Salin |
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| Affiliation: | (1) MirFarm Company, Obninsk, Kaluga Oblast, Russia;(2) Center for Drug Chemistry, All-Russia Research Institute of Pharmaceutical Chemistry, Moscow, 119815, Russia; |
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| Abstract: | A series of new piperid-4-ylethane derivatives possessing antiarrhythmic activity has been synthesized and studied. The most active compound, 1-(4-fluorophenyl)-1-(4-nitrobenzoylamino)-2-(N-ethylpiperid-4-yl)ethane (niferidyl) hydrochloride, was selected for clinical trials as a potential class III antiarrhythmic drug. |
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