A case of diffuse-type primary hepatic lymphoma mimicking diffuse hepatocellular carcinoma |
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Authors: | Koichiro Kaneko Akihiro Nishie Fumitou Arima Tsuyoshi Yoshida Ken Ono Junichi Omagari Hiroshi Honda |
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Affiliation: | (1) PET Imaging Center, Koga Hospital 21, 3-3-8 Miyanojin, Kurume 839-0801, Japan;(2) Department of Hematology, Koga Hospital 21, 3-3-8 Miyanojin, Kurume 839-0801, Japan;(3) Department of Radiology, Koga Hospital 21, 3-3-8 Miyanojin, Kurume 839-0801, Japan;(4) Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan |
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Abstract: | Primary hepatic lymphoma (PHL) is a very rare disease, especially in the diffuse type. We report a case of a middle-aged man with hepatitis C virus infection who developed diffuse-type PHL mimicking diffuse hepatocellular carcinoma (HCC). Contrast-enhanced computed tomography (CT) and magnetic resonance imaging showed diffusely infiltrated hypovascular lesions throughout the liver, but no intrahepatic portal venous thrombus was observed. Diffusion-weighted imaging and 18F-FDG positron emission tomography/CT, respectively, showed a very low apparent diffusion coefficient value and high FDG uptake. These findings were more suggestive of diffuse-type PHL than diffuse HCC. Liver biopsy examination confirmed a diagnosis of diffuse large B-cell lymphoma. Systemic staging revealed no evidence of nodal or bone marrow involvement, so PHL was diagnosed. The patient was treated with chemotherapy and achieved complete remission. We suggest that a combination of image modalities may enable differentiation of diffuse-type PHL from diffuse HCC. |
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